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Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs
The neurosteroid allopregnanolone (ALLO) is under investigation as a treatment for benzodiazepine‐refractory status epilepticus (SE). Here, we assess the cardiopulmonary safety of intravenous ALLO by itself and after a clinically recommended dose of midazolam (MDZ) in two healthy adult beagles. Each...
Autores principales: | Bruun, Donald A., Ma, Betty, Chen, Yi‐Je, Wu, Chun‐Yi, Aleman, Monica, Zolkowska, Dorota, Smiley‐Jewell, Suzette M., Rogawski, Michael A., Lein, Pamela J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235566/ https://www.ncbi.nlm.nih.gov/pubmed/36919379 http://dx.doi.org/10.1002/epi4.12723 |
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