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Deciphering immune microenvironment and cell evasion mechanisms in human gliomas

Gliomas are considered one of the most malignant cancers in the body. Despite current therapies, including surgery, chemotherapy, and radiotherapy, these tumors usually recur with more aggressive and resistant phenotypes. Indeed, the survival following these conventional therapies is very poor, whic...

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Autores principales: Rafii, Soumaya, Kandoussi, Sarah, Ghouzlani, Amina, Naji, Oumayma, Reddy, Konala Priyanka, Ullah Sadiqi, Rizwan, Badou, Abdallah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235598/
https://www.ncbi.nlm.nih.gov/pubmed/37274252
http://dx.doi.org/10.3389/fonc.2023.1135430
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author Rafii, Soumaya
Kandoussi, Sarah
Ghouzlani, Amina
Naji, Oumayma
Reddy, Konala Priyanka
Ullah Sadiqi, Rizwan
Badou, Abdallah
author_facet Rafii, Soumaya
Kandoussi, Sarah
Ghouzlani, Amina
Naji, Oumayma
Reddy, Konala Priyanka
Ullah Sadiqi, Rizwan
Badou, Abdallah
author_sort Rafii, Soumaya
collection PubMed
description Gliomas are considered one of the most malignant cancers in the body. Despite current therapies, including surgery, chemotherapy, and radiotherapy, these tumors usually recur with more aggressive and resistant phenotypes. Indeed, the survival following these conventional therapies is very poor, which makes immunotherapy the subject of active research at present. The anti-tumor immune response could also be considered a prognostic factor since each stage of cancer development is regulated by immune cells. However, glioma microenvironment contains malignant cells that secrete numerous chemokines, cytokines and growth factors, promoting the infiltration of immunosuppressive cells into the tumor, which limit the functioning of the immune system against glioma cells. Recently, researchers have been able to reverse the immune resistance of cancer cells and thus activate the anti-tumor immune response through different immunotherapy strategies. Here, we review the general concept of glioma’s immune microenvironment and report the impact of its distinct components on the anti-tumor immune response. We also discuss the mechanisms of glioma cell evasion from the immune response and pinpoint some potential therapeutic pathways, which could alleviate such resistance.
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spelling pubmed-102355982023-06-03 Deciphering immune microenvironment and cell evasion mechanisms in human gliomas Rafii, Soumaya Kandoussi, Sarah Ghouzlani, Amina Naji, Oumayma Reddy, Konala Priyanka Ullah Sadiqi, Rizwan Badou, Abdallah Front Oncol Oncology Gliomas are considered one of the most malignant cancers in the body. Despite current therapies, including surgery, chemotherapy, and radiotherapy, these tumors usually recur with more aggressive and resistant phenotypes. Indeed, the survival following these conventional therapies is very poor, which makes immunotherapy the subject of active research at present. The anti-tumor immune response could also be considered a prognostic factor since each stage of cancer development is regulated by immune cells. However, glioma microenvironment contains malignant cells that secrete numerous chemokines, cytokines and growth factors, promoting the infiltration of immunosuppressive cells into the tumor, which limit the functioning of the immune system against glioma cells. Recently, researchers have been able to reverse the immune resistance of cancer cells and thus activate the anti-tumor immune response through different immunotherapy strategies. Here, we review the general concept of glioma’s immune microenvironment and report the impact of its distinct components on the anti-tumor immune response. We also discuss the mechanisms of glioma cell evasion from the immune response and pinpoint some potential therapeutic pathways, which could alleviate such resistance. Frontiers Media S.A. 2023-05-19 /pmc/articles/PMC10235598/ /pubmed/37274252 http://dx.doi.org/10.3389/fonc.2023.1135430 Text en Copyright © 2023 Rafii, Kandoussi, Ghouzlani, Naji, Reddy, Ullah Sadiqi and Badou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Rafii, Soumaya
Kandoussi, Sarah
Ghouzlani, Amina
Naji, Oumayma
Reddy, Konala Priyanka
Ullah Sadiqi, Rizwan
Badou, Abdallah
Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
title Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
title_full Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
title_fullStr Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
title_full_unstemmed Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
title_short Deciphering immune microenvironment and cell evasion mechanisms in human gliomas
title_sort deciphering immune microenvironment and cell evasion mechanisms in human gliomas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235598/
https://www.ncbi.nlm.nih.gov/pubmed/37274252
http://dx.doi.org/10.3389/fonc.2023.1135430
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