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Immunometabolic reprogramming, another cancer hallmark

Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key biological processes. The complexity of cancer pathogenesis is best illustrated in the six hallmarks of the cancer: (1) the development of self-sufficient growth signals, (2) the emergence of clones that are...

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Detalles Bibliográficos
Autores principales: Kumar, Vijay, Stewart, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235624/
https://www.ncbi.nlm.nih.gov/pubmed/37275901
http://dx.doi.org/10.3389/fimmu.2023.1125874
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author Kumar, Vijay
Stewart, John H.
author_facet Kumar, Vijay
Stewart, John H.
author_sort Kumar, Vijay
collection PubMed
description Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key biological processes. The complexity of cancer pathogenesis is best illustrated in the six hallmarks of the cancer: (1) the development of self-sufficient growth signals, (2) the emergence of clones that are resistant to apoptosis, (3) resistance to the antigrowth signals, (4) neo-angiogenesis, (5) the invasion of normal tissue or spread to the distant organs, and (6) limitless replicative potential. It also appears that non-resolving inflammation leads to the dysregulation of immune cell metabolism and subsequent cancer progression. The present article delineates immunometabolic reprogramming as a critical hallmark of cancer by linking chronic inflammation and immunosuppression to cancer growth and metastasis. We propose that targeting tumor immunometabolic reprogramming will lead to the design of novel immunotherapeutic approaches to cancer.
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spelling pubmed-102356242023-06-03 Immunometabolic reprogramming, another cancer hallmark Kumar, Vijay Stewart, John H. Front Immunol Immunology Molecular carcinogenesis is a multistep process that involves acquired abnormalities in key biological processes. The complexity of cancer pathogenesis is best illustrated in the six hallmarks of the cancer: (1) the development of self-sufficient growth signals, (2) the emergence of clones that are resistant to apoptosis, (3) resistance to the antigrowth signals, (4) neo-angiogenesis, (5) the invasion of normal tissue or spread to the distant organs, and (6) limitless replicative potential. It also appears that non-resolving inflammation leads to the dysregulation of immune cell metabolism and subsequent cancer progression. The present article delineates immunometabolic reprogramming as a critical hallmark of cancer by linking chronic inflammation and immunosuppression to cancer growth and metastasis. We propose that targeting tumor immunometabolic reprogramming will lead to the design of novel immunotherapeutic approaches to cancer. Frontiers Media S.A. 2023-05-19 /pmc/articles/PMC10235624/ /pubmed/37275901 http://dx.doi.org/10.3389/fimmu.2023.1125874 Text en Copyright © 2023 Kumar and Stewart https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kumar, Vijay
Stewart, John H.
Immunometabolic reprogramming, another cancer hallmark
title Immunometabolic reprogramming, another cancer hallmark
title_full Immunometabolic reprogramming, another cancer hallmark
title_fullStr Immunometabolic reprogramming, another cancer hallmark
title_full_unstemmed Immunometabolic reprogramming, another cancer hallmark
title_short Immunometabolic reprogramming, another cancer hallmark
title_sort immunometabolic reprogramming, another cancer hallmark
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235624/
https://www.ncbi.nlm.nih.gov/pubmed/37275901
http://dx.doi.org/10.3389/fimmu.2023.1125874
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