Implications of specific lysine residues within ataxin-3 for the molecular pathogenesis of Machado-Joseph disease

Lysine residues are one of the main sites for posttranslational modifications of proteins, and lysine ubiquitination of the Machado-Joseph disease protein ataxin-3 is implicated in its cellular function and polyglutamine expansion-dependent toxicity. Despite previously undertaken efforts, the indivi...

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Detalles Bibliográficos
Autores principales: Pereira Sena, Priscila, Weber, Jonasz Jeremiasz, Bayezit, Sercan, Saup, Rafael, Incebacak Eltemur, Rana Dilara, Li, Xiaoling, Velic, Ana, Jung, Jaqueline, Macek, Boris, Nguyen, Huu Phuc, Riess, Olaf, Schmidt, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235640/
https://www.ncbi.nlm.nih.gov/pubmed/37273907
http://dx.doi.org/10.3389/fnmol.2023.1133271

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