Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells

Introduction: Hepsin is a type II transmembrane serine protease and its expression has been linked to greater tumorigenicity and worse prognosis in different tumors. Recently, our group demonstrated that high hepsin levels from primary tumor were associated with a higher risk of metastasis and throm...

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Detalles Bibliográficos
Autores principales: Rodenas, Maria Carmen, Peñas-Martínez, Julia, Pardo-Sánchez, Irene, Zaragoza-Huesca, David, Ortega-Sabater, Carmen, Peña-García, Jorge, Espín, Salvador, Ricote, Guillermo, Montenegro, Sofía, Ayala-De La Peña, Francisco, Luengo-Gil, Ginés, Nieto, Andrés, García-Molina, Francisco, Vicente, Vicente, Bernardi, Francesco, Lozano, María Luisa, Mulero, Victoriano, Pérez-Sánchez, Horacio, Carmona-Bayonas, Alberto, Martínez-Martínez, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235687/
https://www.ncbi.nlm.nih.gov/pubmed/37275957
http://dx.doi.org/10.3389/fmolb.2023.1182925

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