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Delayed and limited administration of the JAKinib tofacitinib mitigates chronic DSS-induced colitis

In inflammatory bowel disease, dysregulated T cells express pro-inflammatory cytokines. Using a chronic azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis model resembling ulcerative colitis, we evaluated whether and when treatment with the Janus kinase (JAK) inhibitor tofacitinib could...

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Detalles Bibliográficos
Autores principales:	Seal, Rishav, Schwab, Lara S. U., Chiarolla, Cristina M., Hundhausen, Nadine, Klose, Georg Heinrich, Reu-Hofer, Simone, Rosenwald, Andreas, Wiest, Johannes, Berberich-Siebelt, Friederike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235777/ https://www.ncbi.nlm.nih.gov/pubmed/37275854 http://dx.doi.org/10.3389/fimmu.2023.1179311

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