Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre

BACKGROUND: Leishmaniasis is a neglected tropical disease that is imported by travellers returning to the UK. Given the prolonged therapy required, outpatient treatment has been proven to be cost-effective and safe. METHODS: We describe cases of leishmaniasis treated through outpatient parenteral an...

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Autores principales: Parkash, Vivak, Laundy, Nicholas, Durojaiye, Oyewole Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235804/
https://www.ncbi.nlm.nih.gov/pubmed/36610796
http://dx.doi.org/10.1093/trstmh/trac128
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author Parkash, Vivak
Laundy, Nicholas
Durojaiye, Oyewole Christopher
author_facet Parkash, Vivak
Laundy, Nicholas
Durojaiye, Oyewole Christopher
author_sort Parkash, Vivak
collection PubMed
description BACKGROUND: Leishmaniasis is a neglected tropical disease that is imported by travellers returning to the UK. Given the prolonged therapy required, outpatient treatment has been proven to be cost-effective and safe. METHODS: We describe cases of leishmaniasis treated through outpatient parenteral antimicrobial therapy (OPAT) over a 13-y period (March 2006–September 2018) at a large teaching hospital. RESULTS: A total of 26 episodes of leishmaniasis were treated successfully, with a mean saving of 14.2 bed-days/episode. Sodium stibogluconate was the most used antileishmanial (92%). CONCLUSIONS: Treatment of chronic infections via OPAT is now commonplace and this approach may be considered for other imported infectious diseases.
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spelling pubmed-102358042023-06-03 Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre Parkash, Vivak Laundy, Nicholas Durojaiye, Oyewole Christopher Trans R Soc Trop Med Hyg Short Communication BACKGROUND: Leishmaniasis is a neglected tropical disease that is imported by travellers returning to the UK. Given the prolonged therapy required, outpatient treatment has been proven to be cost-effective and safe. METHODS: We describe cases of leishmaniasis treated through outpatient parenteral antimicrobial therapy (OPAT) over a 13-y period (March 2006–September 2018) at a large teaching hospital. RESULTS: A total of 26 episodes of leishmaniasis were treated successfully, with a mean saving of 14.2 bed-days/episode. Sodium stibogluconate was the most used antileishmanial (92%). CONCLUSIONS: Treatment of chronic infections via OPAT is now commonplace and this approach may be considered for other imported infectious diseases. Oxford University Press 2023-01-05 /pmc/articles/PMC10235804/ /pubmed/36610796 http://dx.doi.org/10.1093/trstmh/trac128 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Parkash, Vivak
Laundy, Nicholas
Durojaiye, Oyewole Christopher
Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre
title Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre
title_full Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre
title_fullStr Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre
title_full_unstemmed Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre
title_short Outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large UK infectious diseases centre
title_sort outpatient parenteral antimicrobial therapy for leishmaniasis: 13 years’ experience at a large uk infectious diseases centre
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235804/
https://www.ncbi.nlm.nih.gov/pubmed/36610796
http://dx.doi.org/10.1093/trstmh/trac128
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