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Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes
The objective of this study was to characterize frailty and resilience in people evaluated for Post-Acute COVID-19 Syndrome (PACS), in relation to quality of life (QoL) and Intrinsic Capacity (IC). This cross-sectional, observational, study included consecutive people previously hospitalized for sev...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235830/ https://www.ncbi.nlm.nih.gov/pubmed/37268716 http://dx.doi.org/10.1038/s41598-023-29408-z |
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author | Guaraldi, Giovanni Milic, Jovana Barbieri, Sara Marchiò, Tommaso Caselgrandi, Agnese Motta, Federico Beghè, Bianca Verduri, Alessia Belli, Michela Gozzi, Licia Iadisernia, Vittorio Faltoni, Matteo Burastero, Giulia Dessilani, Andrea Del Monte, Martina Dolci, Giovanni Bacca, Erica Franceschi, Giacomo Yaacoub, Dina Volpi, Sara Mazzochi, Alice Clini, Enrico Mussini, Cristina |
author_facet | Guaraldi, Giovanni Milic, Jovana Barbieri, Sara Marchiò, Tommaso Caselgrandi, Agnese Motta, Federico Beghè, Bianca Verduri, Alessia Belli, Michela Gozzi, Licia Iadisernia, Vittorio Faltoni, Matteo Burastero, Giulia Dessilani, Andrea Del Monte, Martina Dolci, Giovanni Bacca, Erica Franceschi, Giacomo Yaacoub, Dina Volpi, Sara Mazzochi, Alice Clini, Enrico Mussini, Cristina |
author_sort | Guaraldi, Giovanni |
collection | PubMed |
description | The objective of this study was to characterize frailty and resilience in people evaluated for Post-Acute COVID-19 Syndrome (PACS), in relation to quality of life (QoL) and Intrinsic Capacity (IC). This cross-sectional, observational, study included consecutive people previously hospitalized for severe COVID-19 pneumonia attending Modena (Italy) PACS Clinic from July 2020 to April 2021. Four frailty-resilience phenotypes were built: “fit/resilient”, “fit/non-resilient”, “frail/resilient” and “frail/non-resilient”. Frailty and resilience were defined according to frailty phenotype and Connor Davidson resilience scale (CD-RISC-25) respectively. Study outcomes were: QoL assessed by means of Symptoms Short form health survey (SF-36) and health-related quality of life (EQ-5D-5L) and IC by means of a dedicated questionnaire. Their predictors including frailty-resilience phenotypes were explored in logistic regressions. 232 patients were evaluated, median age was 58.0 years. PACS was diagnosed in 173 (74.6%) patients. Scarce resilience was documented in 114 (49.1%) and frailty in 72 (31.0%) individuals. Predictors for SF-36 score < 61.60 were the phenotypes “frail/non-resilient” (OR = 4.69, CI 2.08–10.55), “fit/non-resilient” (OR = 2.79, CI 1.00–7.73). Predictors for EQ-5D-5L < 89.7% were the phenotypes “frail/non-resilient” (OR = 5.93, CI 2.64–13.33) and “frail/resilient” (OR = 5.66, CI 1.93–16.54). Predictors of impaired IC (below the mean score value) were “frail/non-resilient” (OR = 7.39, CI 3.20–17.07), and “fit/non-resilient” (OR = 4.34, CI 2.16–8.71) phenotypes. Resilience and frailty phenotypes may have a different impact on wellness and QoL and may be evaluated in people with PACS to identify vulnerable individuals that require suitable interventions. |
format | Online Article Text |
id | pubmed-10235830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102358302023-06-04 Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes Guaraldi, Giovanni Milic, Jovana Barbieri, Sara Marchiò, Tommaso Caselgrandi, Agnese Motta, Federico Beghè, Bianca Verduri, Alessia Belli, Michela Gozzi, Licia Iadisernia, Vittorio Faltoni, Matteo Burastero, Giulia Dessilani, Andrea Del Monte, Martina Dolci, Giovanni Bacca, Erica Franceschi, Giacomo Yaacoub, Dina Volpi, Sara Mazzochi, Alice Clini, Enrico Mussini, Cristina Sci Rep Article The objective of this study was to characterize frailty and resilience in people evaluated for Post-Acute COVID-19 Syndrome (PACS), in relation to quality of life (QoL) and Intrinsic Capacity (IC). This cross-sectional, observational, study included consecutive people previously hospitalized for severe COVID-19 pneumonia attending Modena (Italy) PACS Clinic from July 2020 to April 2021. Four frailty-resilience phenotypes were built: “fit/resilient”, “fit/non-resilient”, “frail/resilient” and “frail/non-resilient”. Frailty and resilience were defined according to frailty phenotype and Connor Davidson resilience scale (CD-RISC-25) respectively. Study outcomes were: QoL assessed by means of Symptoms Short form health survey (SF-36) and health-related quality of life (EQ-5D-5L) and IC by means of a dedicated questionnaire. Their predictors including frailty-resilience phenotypes were explored in logistic regressions. 232 patients were evaluated, median age was 58.0 years. PACS was diagnosed in 173 (74.6%) patients. Scarce resilience was documented in 114 (49.1%) and frailty in 72 (31.0%) individuals. Predictors for SF-36 score < 61.60 were the phenotypes “frail/non-resilient” (OR = 4.69, CI 2.08–10.55), “fit/non-resilient” (OR = 2.79, CI 1.00–7.73). Predictors for EQ-5D-5L < 89.7% were the phenotypes “frail/non-resilient” (OR = 5.93, CI 2.64–13.33) and “frail/resilient” (OR = 5.66, CI 1.93–16.54). Predictors of impaired IC (below the mean score value) were “frail/non-resilient” (OR = 7.39, CI 3.20–17.07), and “fit/non-resilient” (OR = 4.34, CI 2.16–8.71) phenotypes. Resilience and frailty phenotypes may have a different impact on wellness and QoL and may be evaluated in people with PACS to identify vulnerable individuals that require suitable interventions. Nature Publishing Group UK 2023-06-02 /pmc/articles/PMC10235830/ /pubmed/37268716 http://dx.doi.org/10.1038/s41598-023-29408-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Guaraldi, Giovanni Milic, Jovana Barbieri, Sara Marchiò, Tommaso Caselgrandi, Agnese Motta, Federico Beghè, Bianca Verduri, Alessia Belli, Michela Gozzi, Licia Iadisernia, Vittorio Faltoni, Matteo Burastero, Giulia Dessilani, Andrea Del Monte, Martina Dolci, Giovanni Bacca, Erica Franceschi, Giacomo Yaacoub, Dina Volpi, Sara Mazzochi, Alice Clini, Enrico Mussini, Cristina Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes |
title | Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes |
title_full | Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes |
title_fullStr | Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes |
title_full_unstemmed | Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes |
title_short | Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes |
title_sort | quality of life and intrinsic capacity in patients with post-acute covid-19 syndrome is in relation to frailty and resilience phenotypes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235830/ https://www.ncbi.nlm.nih.gov/pubmed/37268716 http://dx.doi.org/10.1038/s41598-023-29408-z |
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