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Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia
BACKGROUND: Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition (Myosteatosis). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral myosteatosi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235864/ https://www.ncbi.nlm.nih.gov/pubmed/36892104 http://dx.doi.org/10.1002/jcsm.13192 |
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author | Diallo, Thierno D. Rospleszcz, Susanne Fabian, Jana Walter, Sven S. Maurer, Elke Storz, Corinna Roemer, Frank Rathmann, Wolfgang Peters, Annette Jungmann, Pia M. Jung, Matthias Bamberg, Fabian Kiefer, Lena S. |
author_facet | Diallo, Thierno D. Rospleszcz, Susanne Fabian, Jana Walter, Sven S. Maurer, Elke Storz, Corinna Roemer, Frank Rathmann, Wolfgang Peters, Annette Jungmann, Pia M. Jung, Matthias Bamberg, Fabian Kiefer, Lena S. |
author_sort | Diallo, Thierno D. |
collection | PubMed |
description | BACKGROUND: Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition (Myosteatosis). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral myosteatosis with lumbar disc degeneration in individuals with impaired glucose metabolism and normoglycaemic controls. METHODS: In total, 304 individuals (mean age: 56.3 ± 9.1 years, 53.6% male sex, mean body mass index [BMI]: 27.6 ± 4.7 kg/m(2)) from a population‐based cohort study who underwent 3‐Tesla whole‐body chemical‐shift‐encoded (six echo times) and T2‐weighted single‐shot‐fast‐spin‐echo MRI were included. Lumbar disc degeneration was assessed at motion segments L1 to L5, categorized according to the Pfirrmann score and defined as Pfirrmann grade > 2 and/or disc bulging/herniation on at least one segment. Fat content of the autochthonous back muscles and the quadratus lumborum muscle was quantified as proton density fat fraction (PDFF(muscle)). Logistic regression models adjusted for age, sex, BMI and regular physical activity were calculated to evaluate the association between PDFF(muscle) and outcome IVDD. RESULTS: The overall prevalence of IVDD was 79.6%. There was no significant difference in the prevalence or severity distribution of IVDD between participants with or without impaired glucose metabolism (77.7% vs. 80.7%, P = 0.63 and P = 0.71, respectively). PDFF(muscle) was significantly and positively associated with an increased risk for the presence of IVDD in participants with impaired glycaemia when adjusted for age, sex and BMI (PDFF(autochthonous back muscles): odds ratio [OR] 2.16, 95% confidence interval [CI] [1.09, 4.3], P = 0.03; PDFF(quadratus lumborum): OR 2.01, 95% CI [1.04, 3.85], P = 0.04). After further adjustment for regular physical activity, the results attenuated, albeit approaching statistical significance (PDFF(autochthonous back muscles): OR 1.97, 95% CI [0.97, 3.99], P = 0.06; PDFF(quadratus lumborum): OR 1.86, 95% CI [0.92, 3.76], P = 0.09). No significant associations were shown in healthy controls (PDFF(autochthonous back muscles): OR 0.62, 95% CI [0.34, 1.14], P = 0.13; PDFF(quadratus lumborum): OR 1.06, 95% CI [0.6, 1.89], P = 0.83). CONCLUSIONS: Paravertebral myosteatosis is positively associated with intervertebral disc disease in individuals with impaired glucose metabolism, independent of age, sex and BMI. Regular physical activity may confound these associations. Longitudinal studies will help to better understand the pathophysiological role of skeletal muscle in those with concomitant disturbed glucose haemostasis and intervertebral disc disease, as well as possible underlying causal relationships. |
format | Online Article Text |
id | pubmed-10235864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102358642023-06-03 Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia Diallo, Thierno D. Rospleszcz, Susanne Fabian, Jana Walter, Sven S. Maurer, Elke Storz, Corinna Roemer, Frank Rathmann, Wolfgang Peters, Annette Jungmann, Pia M. Jung, Matthias Bamberg, Fabian Kiefer, Lena S. J Cachexia Sarcopenia Muscle Original Articles BACKGROUND: Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition (Myosteatosis). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral myosteatosis with lumbar disc degeneration in individuals with impaired glucose metabolism and normoglycaemic controls. METHODS: In total, 304 individuals (mean age: 56.3 ± 9.1 years, 53.6% male sex, mean body mass index [BMI]: 27.6 ± 4.7 kg/m(2)) from a population‐based cohort study who underwent 3‐Tesla whole‐body chemical‐shift‐encoded (six echo times) and T2‐weighted single‐shot‐fast‐spin‐echo MRI were included. Lumbar disc degeneration was assessed at motion segments L1 to L5, categorized according to the Pfirrmann score and defined as Pfirrmann grade > 2 and/or disc bulging/herniation on at least one segment. Fat content of the autochthonous back muscles and the quadratus lumborum muscle was quantified as proton density fat fraction (PDFF(muscle)). Logistic regression models adjusted for age, sex, BMI and regular physical activity were calculated to evaluate the association between PDFF(muscle) and outcome IVDD. RESULTS: The overall prevalence of IVDD was 79.6%. There was no significant difference in the prevalence or severity distribution of IVDD between participants with or without impaired glucose metabolism (77.7% vs. 80.7%, P = 0.63 and P = 0.71, respectively). PDFF(muscle) was significantly and positively associated with an increased risk for the presence of IVDD in participants with impaired glycaemia when adjusted for age, sex and BMI (PDFF(autochthonous back muscles): odds ratio [OR] 2.16, 95% confidence interval [CI] [1.09, 4.3], P = 0.03; PDFF(quadratus lumborum): OR 2.01, 95% CI [1.04, 3.85], P = 0.04). After further adjustment for regular physical activity, the results attenuated, albeit approaching statistical significance (PDFF(autochthonous back muscles): OR 1.97, 95% CI [0.97, 3.99], P = 0.06; PDFF(quadratus lumborum): OR 1.86, 95% CI [0.92, 3.76], P = 0.09). No significant associations were shown in healthy controls (PDFF(autochthonous back muscles): OR 0.62, 95% CI [0.34, 1.14], P = 0.13; PDFF(quadratus lumborum): OR 1.06, 95% CI [0.6, 1.89], P = 0.83). CONCLUSIONS: Paravertebral myosteatosis is positively associated with intervertebral disc disease in individuals with impaired glucose metabolism, independent of age, sex and BMI. Regular physical activity may confound these associations. Longitudinal studies will help to better understand the pathophysiological role of skeletal muscle in those with concomitant disturbed glucose haemostasis and intervertebral disc disease, as well as possible underlying causal relationships. John Wiley and Sons Inc. 2023-03-09 /pmc/articles/PMC10235864/ /pubmed/36892104 http://dx.doi.org/10.1002/jcsm.13192 Text en © 2023 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Diallo, Thierno D. Rospleszcz, Susanne Fabian, Jana Walter, Sven S. Maurer, Elke Storz, Corinna Roemer, Frank Rathmann, Wolfgang Peters, Annette Jungmann, Pia M. Jung, Matthias Bamberg, Fabian Kiefer, Lena S. Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia |
title | Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia |
title_full | Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia |
title_fullStr | Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia |
title_full_unstemmed | Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia |
title_short | Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia |
title_sort | associations of myosteatosis with disc degeneration: a 3t magnetic resonance imaging study in individuals with impaired glycaemia |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235864/ https://www.ncbi.nlm.nih.gov/pubmed/36892104 http://dx.doi.org/10.1002/jcsm.13192 |
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