TRPV1 activation in human Langerhans cells and T cells inhibits mucosal HIV-1 infection via CGRP-dependent and independent mechanisms

Upon its mucosal transmission, HIV type 1 (HIV-1) rapidly targets genital antigen-presenting Langerhans cells (LCs), which subsequently transfer infectious virus to CD4(+) T cells. We previously described an inhibitory neuroimmune cross talk, whereby calcitonin gene-related peptide (CGRP), a neurope...

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Detalles Bibliográficos
Autores principales: Mariotton, Jammy, Cohen, Emmanuel, Zhu, Aiwei, Auffray, Cédric, Barbosa Bomfim, Caio César, Barry Delongchamps, Nicolas, Zerbib, Marc, Bomsel, Morgane, Ganor, Yonatan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235960/
https://www.ncbi.nlm.nih.gov/pubmed/37216549
http://dx.doi.org/10.1073/pnas.2302509120

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