ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation

Exploring the potential lead compounds for Alzheimer’s disease (AD) remains one of the challenging tasks. Here, we report that the plant extract conophylline (CNP) impeded amyloidogenesis by preferentially inhibiting BACE1 translation via the 5′ untranslated region (5′UTR) and rescued cognitive decl...

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Detalles Bibliográficos
Autores principales: Zhou, Gui-Feng, Tang, Jing, Ma, Yuan-Lin, Fu, Xian, Liu, Jun-Yan, Yang, Ren-Zhi, Zhang, Hong-Sheng, Cai, Xiang-Hai, Wang, Jing-Wen, Xie, Xiao-Yong, Song, Li, Luo, Biao, Chen, Jian, Chen, Long, Deng, Xiao-Juan, Chen, Guo-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235968/
https://www.ncbi.nlm.nih.gov/pubmed/37216506
http://dx.doi.org/10.1073/pnas.2220148120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235968/
https://www.ncbi.nlm.nih.gov/pubmed/37216506
http://dx.doi.org/10.1073/pnas.2220148120

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