Cryo-EM structure of the Mon1–Ccz1–RMC1 complex reveals molecular basis of metazoan RAB7A activation

Understanding of the evolution of metazoans from their unicellular ancestors is a fundamental question in biology. In contrast to fungi which utilize the Mon1–Ccz1 dimeric complex to activate the small GTPase RAB7A, metazoans rely on the Mon1–Ccz1–RMC1 trimeric complex. Here, we report a near-atomic...

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Detalles Bibliográficos
Autores principales: Yong, Xin, Jia, Guowen, Liu, Zhe, Zhou, Chunzhuang, Yi, Jiamin, Tang, Yingying, Chen, Li, Chen, Lu, Wang, Yuan, Sun, Qingxiang, Billadeau, Daniel D., Su, Zhaoming, Jia, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235969/
https://www.ncbi.nlm.nih.gov/pubmed/37216550
http://dx.doi.org/10.1073/pnas.2301725120

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