T Cells Expressing a Modified FcγRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors

The pioneering design of chimeric antigen receptor (CAR) T-cell therapy demonstrated the potential of reprogramming the immune system. Nonetheless, T-cell exhaustion, toxicity, and suppressive microenvironments limit their efficacy in solid tumors. We previously characterized a subset of tumor-infil...

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Detalles Bibliográficos
Autores principales: Rasoulouniriana, Diana, Santana-Magal, Nadine, Gutwillig, Amit, Farhat-Younis, Leen, Tal, Lior, Amar, Sarah, Milyavsky, Michael, Muddineni, Siva Sai Naga Anurag, Solomon, Neta, Shpilt, Hana, Dotan, Shahar, Pilpel, Noam, Waskow, Claudia, Feinmesser, Meora, Rider, Peleg, Carmi, Yaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236152/
https://www.ncbi.nlm.nih.gov/pubmed/37070661
http://dx.doi.org/10.1158/2326-6066.CIR-22-0423

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