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HIPK2 in the physiology of nervous system and its implications in neurological disorders

HIPK2 is an evolutionary conserved serine/threonine kinase with multifunctional roles in stress response, embryonic development and pathological conditions, such as cancer and fibrosis. The heterogeneity of its interactors and targets makes HIPK2 activity strongly dependent on the cellular context,...

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Autores principales: Sardina, F., Conte, A., Paladino, S., Pierantoni, G.M., Rinaldo, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236203/
https://www.ncbi.nlm.nih.gov/pubmed/36935052
http://dx.doi.org/10.1016/j.bbamcr.2023.119465
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author Sardina, F.
Conte, A.
Paladino, S.
Pierantoni, G.M.
Rinaldo, C.
author_facet Sardina, F.
Conte, A.
Paladino, S.
Pierantoni, G.M.
Rinaldo, C.
author_sort Sardina, F.
collection PubMed
description HIPK2 is an evolutionary conserved serine/threonine kinase with multifunctional roles in stress response, embryonic development and pathological conditions, such as cancer and fibrosis. The heterogeneity of its interactors and targets makes HIPK2 activity strongly dependent on the cellular context, and allows it to modulate multiple signaling pathways, ultimately regulating cell fate and proliferation. HIPK2 is highly expressed in the central and peripheral nervous systems, and its genetic ablation causes neurological defects in mice. Moreover, HIPK2 is involved in processes, such as endoplasmic reticulum stress response and protein aggregate accumulation, and pathways, including TGF-β and BMP signaling, that are crucial in the pathogenesis of neurological disorders. Here, we review the data about the role of HIPK2 in neuronal development, survival, and homeostasis, highlighting the implications in the pathogenesis of neurological disorders, and pointing out HIPK2 potentiality as therapeutic target and diagnostic or prognostic marker.
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spelling pubmed-102362032023-06-03 HIPK2 in the physiology of nervous system and its implications in neurological disorders Sardina, F. Conte, A. Paladino, S. Pierantoni, G.M. Rinaldo, C. Biochim Biophys Acta Mol Cell Res Article HIPK2 is an evolutionary conserved serine/threonine kinase with multifunctional roles in stress response, embryonic development and pathological conditions, such as cancer and fibrosis. The heterogeneity of its interactors and targets makes HIPK2 activity strongly dependent on the cellular context, and allows it to modulate multiple signaling pathways, ultimately regulating cell fate and proliferation. HIPK2 is highly expressed in the central and peripheral nervous systems, and its genetic ablation causes neurological defects in mice. Moreover, HIPK2 is involved in processes, such as endoplasmic reticulum stress response and protein aggregate accumulation, and pathways, including TGF-β and BMP signaling, that are crucial in the pathogenesis of neurological disorders. Here, we review the data about the role of HIPK2 in neuronal development, survival, and homeostasis, highlighting the implications in the pathogenesis of neurological disorders, and pointing out HIPK2 potentiality as therapeutic target and diagnostic or prognostic marker. Elsevier 2023-06 /pmc/articles/PMC10236203/ /pubmed/36935052 http://dx.doi.org/10.1016/j.bbamcr.2023.119465 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sardina, F.
Conte, A.
Paladino, S.
Pierantoni, G.M.
Rinaldo, C.
HIPK2 in the physiology of nervous system and its implications in neurological disorders
title HIPK2 in the physiology of nervous system and its implications in neurological disorders
title_full HIPK2 in the physiology of nervous system and its implications in neurological disorders
title_fullStr HIPK2 in the physiology of nervous system and its implications in neurological disorders
title_full_unstemmed HIPK2 in the physiology of nervous system and its implications in neurological disorders
title_short HIPK2 in the physiology of nervous system and its implications in neurological disorders
title_sort hipk2 in the physiology of nervous system and its implications in neurological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236203/
https://www.ncbi.nlm.nih.gov/pubmed/36935052
http://dx.doi.org/10.1016/j.bbamcr.2023.119465
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