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Effects of allium cepa on ovarian torsion-detorsion injury in a rat model

OBJECTIVE: Ischemia/reperfusion (I/R) damage following detorsion treatment, tissue fibrosis, and adhesions cause secondary tissue damage in the ovaries. Many studies have been evaluated to minimize antioxidant damage in ovarian reserve loss while minimizing I/R damage. However, no study observed lon...

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Autores principales: Kula, Hakan, İlgen, Orkun, Kurt, Sefa, Yılmaz, Filiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236230/
https://www.ncbi.nlm.nih.gov/pubmed/37260222
http://dx.doi.org/10.4274/tjod.galenos.2023.41763
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author Kula, Hakan
İlgen, Orkun
Kurt, Sefa
Yılmaz, Filiz
author_facet Kula, Hakan
İlgen, Orkun
Kurt, Sefa
Yılmaz, Filiz
author_sort Kula, Hakan
collection PubMed
description OBJECTIVE: Ischemia/reperfusion (I/R) damage following detorsion treatment, tissue fibrosis, and adhesions cause secondary tissue damage in the ovaries. Many studies have been evaluated to minimize antioxidant damage in ovarian reserve loss while minimizing I/R damage. However, no study observed long-term effects on the ovarian torsion model in rats. In this study, we evaluated the profibrotic effects of A. cepa on an ovarian torsion model on rats. MATERIALS AND METHODS: Group I (n=7) rats were the sham group. Group II (n=7) rats were the torsion group and Group III (n=7) rats were the torsion + A. cepa group. To observe the long-term effects of allium cepa, rats were fed for 21 days. Cellular damage I/R is evaluated by histopathological damage score, and transforming growth factor-beta 1 (TGF-β1) and alpha-smooth muscle actin (α-SMA) is measured to analyze the profibrotic effect. RESULTS: A. cepa altered cellular damage due to improvement in the histopathological damage score with A. cepa intake. However, the profibrotic mediators TGF-β1 and α-SMA are non- significantly changed by the A. cepa (p=0.477 and p=0.185 respectively). CONCLUSION: A. cepa is a potent protective on cellular tissue, minimizing I/R damage on ovarian tissue histologically. Our study implies that A. cepa does not affect fibrosis-related mediators in the rat ovary.
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spelling pubmed-102362302023-06-03 Effects of allium cepa on ovarian torsion-detorsion injury in a rat model Kula, Hakan İlgen, Orkun Kurt, Sefa Yılmaz, Filiz Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: Ischemia/reperfusion (I/R) damage following detorsion treatment, tissue fibrosis, and adhesions cause secondary tissue damage in the ovaries. Many studies have been evaluated to minimize antioxidant damage in ovarian reserve loss while minimizing I/R damage. However, no study observed long-term effects on the ovarian torsion model in rats. In this study, we evaluated the profibrotic effects of A. cepa on an ovarian torsion model on rats. MATERIALS AND METHODS: Group I (n=7) rats were the sham group. Group II (n=7) rats were the torsion group and Group III (n=7) rats were the torsion + A. cepa group. To observe the long-term effects of allium cepa, rats were fed for 21 days. Cellular damage I/R is evaluated by histopathological damage score, and transforming growth factor-beta 1 (TGF-β1) and alpha-smooth muscle actin (α-SMA) is measured to analyze the profibrotic effect. RESULTS: A. cepa altered cellular damage due to improvement in the histopathological damage score with A. cepa intake. However, the profibrotic mediators TGF-β1 and α-SMA are non- significantly changed by the A. cepa (p=0.477 and p=0.185 respectively). CONCLUSION: A. cepa is a potent protective on cellular tissue, minimizing I/R damage on ovarian tissue histologically. Our study implies that A. cepa does not affect fibrosis-related mediators in the rat ovary. Galenos Publishing 2023-06 2023-06-01 /pmc/articles/PMC10236230/ /pubmed/37260222 http://dx.doi.org/10.4274/tjod.galenos.2023.41763 Text en ©Copyright 2023 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Kula, Hakan
İlgen, Orkun
Kurt, Sefa
Yılmaz, Filiz
Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
title Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
title_full Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
title_fullStr Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
title_full_unstemmed Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
title_short Effects of allium cepa on ovarian torsion-detorsion injury in a rat model
title_sort effects of allium cepa on ovarian torsion-detorsion injury in a rat model
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236230/
https://www.ncbi.nlm.nih.gov/pubmed/37260222
http://dx.doi.org/10.4274/tjod.galenos.2023.41763
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