Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia

Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease,...

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Autores principales: Var, Susanna R., Strell, Phoebe, Johnson, Sether T., Roman, Alex, Vasilakos, Zoey, Low, Walter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236244/
https://www.ncbi.nlm.nih.gov/pubmed/37254858
http://dx.doi.org/10.1177/09636897231171001
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author Var, Susanna R.
Strell, Phoebe
Johnson, Sether T.
Roman, Alex
Vasilakos, Zoey
Low, Walter C.
author_facet Var, Susanna R.
Strell, Phoebe
Johnson, Sether T.
Roman, Alex
Vasilakos, Zoey
Low, Walter C.
author_sort Var, Susanna R.
collection PubMed
description Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, and CNS-related injuries, and can accelerate or worsen the condition. Transplantation studies designed to replace and supplement dysfunctional microglia with healthy microglia offer a promising strategy for addressing microglia-mediated neuroinflammation and pathologies. This review will cover microglial involvement in neurological diseases and disorders and CNS-related injuries, current microglial transplantation strategies, and different approaches and considerations for generating exogenic microglia.
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spelling pubmed-102362442023-06-03 Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia Var, Susanna R. Strell, Phoebe Johnson, Sether T. Roman, Alex Vasilakos, Zoey Low, Walter C. Cell Transplant Review Microglia are associated with a wide range of both neuroprotective and neuroinflammatory functions in the central nervous system (CNS) during development and throughout lifespan. Chronically activated and dysfunctional microglia are found in many diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, and CNS-related injuries, and can accelerate or worsen the condition. Transplantation studies designed to replace and supplement dysfunctional microglia with healthy microglia offer a promising strategy for addressing microglia-mediated neuroinflammation and pathologies. This review will cover microglial involvement in neurological diseases and disorders and CNS-related injuries, current microglial transplantation strategies, and different approaches and considerations for generating exogenic microglia. SAGE Publications 2023-05-31 /pmc/articles/PMC10236244/ /pubmed/37254858 http://dx.doi.org/10.1177/09636897231171001 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Var, Susanna R.
Strell, Phoebe
Johnson, Sether T.
Roman, Alex
Vasilakos, Zoey
Low, Walter C.
Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
title Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
title_full Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
title_fullStr Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
title_full_unstemmed Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
title_short Transplanting Microglia for Treating CNS Injuries and Neurological Diseases and Disorders, and Prospects for Generating Exogenic Microglia
title_sort transplanting microglia for treating cns injuries and neurological diseases and disorders, and prospects for generating exogenic microglia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236244/
https://www.ncbi.nlm.nih.gov/pubmed/37254858
http://dx.doi.org/10.1177/09636897231171001
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