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3D printing of biomaterials for vascularized and innervated tissue regeneration
Neurovascular networks play significant roles in the metabolism and regeneration of many tissues and organs in the human body. Blood vessels can transport sufficient oxygen, nutrients, and biological factors, while nerve fibers transmit excitation signals to targeted cells. However, traditional scaf...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Whioce Publishing Pte. Ltd.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236343/ https://www.ncbi.nlm.nih.gov/pubmed/37273994 http://dx.doi.org/10.18063/ijb.706 |
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author | Zhang, Hongjian Wu, Chengtie |
author_facet | Zhang, Hongjian Wu, Chengtie |
author_sort | Zhang, Hongjian |
collection | PubMed |
description | Neurovascular networks play significant roles in the metabolism and regeneration of many tissues and organs in the human body. Blood vessels can transport sufficient oxygen, nutrients, and biological factors, while nerve fibers transmit excitation signals to targeted cells. However, traditional scaffolds cannot satisfy the requirement of stimulating angiogenesis and innervation in a timely manner due to the complexity of host neurovascular networks. Three-dimensional (3D) printing, as a versatile and favorable technique, provides an effective approach to fabricating biological scaffolds with biomimetic architectures and multimaterial compositions, which are capable of regulating multiple cell behaviors. This review paper presents a summary of the current progress in 3D-printed biomaterials for vascularized and innervated tissue regeneration by presenting skin, bone, and skeletal muscle tissues as an example. In addition, we highlight the crucial roles of blood vessels and nerve fibers in the process of tissue regeneration and discuss the future perspectives for engineering novel biomaterials. It is expected that 3D-printed biomaterials with angiogenesis and innervation properties can not only recapitulate the physiological microenvironment of damaged tissues but also rapidly integrate with host neurovascular networks, resulting in accelerated functional tissue regeneration. |
format | Online Article Text |
id | pubmed-10236343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Whioce Publishing Pte. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102363432023-06-03 3D printing of biomaterials for vascularized and innervated tissue regeneration Zhang, Hongjian Wu, Chengtie Int J Bioprint Research Article Neurovascular networks play significant roles in the metabolism and regeneration of many tissues and organs in the human body. Blood vessels can transport sufficient oxygen, nutrients, and biological factors, while nerve fibers transmit excitation signals to targeted cells. However, traditional scaffolds cannot satisfy the requirement of stimulating angiogenesis and innervation in a timely manner due to the complexity of host neurovascular networks. Three-dimensional (3D) printing, as a versatile and favorable technique, provides an effective approach to fabricating biological scaffolds with biomimetic architectures and multimaterial compositions, which are capable of regulating multiple cell behaviors. This review paper presents a summary of the current progress in 3D-printed biomaterials for vascularized and innervated tissue regeneration by presenting skin, bone, and skeletal muscle tissues as an example. In addition, we highlight the crucial roles of blood vessels and nerve fibers in the process of tissue regeneration and discuss the future perspectives for engineering novel biomaterials. It is expected that 3D-printed biomaterials with angiogenesis and innervation properties can not only recapitulate the physiological microenvironment of damaged tissues but also rapidly integrate with host neurovascular networks, resulting in accelerated functional tissue regeneration. Whioce Publishing Pte. Ltd. 2023-03-10 /pmc/articles/PMC10236343/ /pubmed/37273994 http://dx.doi.org/10.18063/ijb.706 Text en Copyright:© 2023, Zhang H, Wu C https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Hongjian Wu, Chengtie 3D printing of biomaterials for vascularized and innervated tissue regeneration |
title | 3D printing of biomaterials for vascularized and innervated tissue regeneration |
title_full | 3D printing of biomaterials for vascularized and innervated tissue regeneration |
title_fullStr | 3D printing of biomaterials for vascularized and innervated tissue regeneration |
title_full_unstemmed | 3D printing of biomaterials for vascularized and innervated tissue regeneration |
title_short | 3D printing of biomaterials for vascularized and innervated tissue regeneration |
title_sort | 3d printing of biomaterials for vascularized and innervated tissue regeneration |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236343/ https://www.ncbi.nlm.nih.gov/pubmed/37273994 http://dx.doi.org/10.18063/ijb.706 |
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