Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations

We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLN(ZMYM2::FGFR1)) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then t...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Dong, Liu, Guang, Lewis, Michael R., Li, Xia, Ulrickson, Matthew, Nath, Rajneesh, Chen, Weina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236454/
https://www.ncbi.nlm.nih.gov/pubmed/37275466
http://dx.doi.org/10.1016/j.lrr.2023.100370
_version_ 1785052922347782144
author Chen, Dong
Liu, Guang
Lewis, Michael R.
Li, Xia
Ulrickson, Matthew
Nath, Rajneesh
Chen, Weina
author_facet Chen, Dong
Liu, Guang
Lewis, Michael R.
Li, Xia
Ulrickson, Matthew
Nath, Rajneesh
Chen, Weina
author_sort Chen, Dong
collection PubMed
description We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLN(ZMYM2::FGFR1)) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then transitioned to systemic mastocytosis (SM) likely accompanied by additional JAK3 and other mutations and finally transformed to acute myeloid leukemia (AML) accompanied by additional/secondary genetic abnormality (gain of chromosome 21, der(13)t(8;13), and RUNX1 mutation). To our knowledge, this is the first case of MLN(ZMYM2::FGFR1) with a complex trilineage/phenotypic [T-cell (T-LBL), mast cell (SM), and myeloid (MPN and AML)] lineage evolution.
format Online
Article
Text
id pubmed-10236454
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-102364542023-06-03 Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations Chen, Dong Liu, Guang Lewis, Michael R. Li, Xia Ulrickson, Matthew Nath, Rajneesh Chen, Weina Leuk Res Rep Article We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLN(ZMYM2::FGFR1)) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then transitioned to systemic mastocytosis (SM) likely accompanied by additional JAK3 and other mutations and finally transformed to acute myeloid leukemia (AML) accompanied by additional/secondary genetic abnormality (gain of chromosome 21, der(13)t(8;13), and RUNX1 mutation). To our knowledge, this is the first case of MLN(ZMYM2::FGFR1) with a complex trilineage/phenotypic [T-cell (T-LBL), mast cell (SM), and myeloid (MPN and AML)] lineage evolution. Elsevier 2023-05-26 /pmc/articles/PMC10236454/ /pubmed/37275466 http://dx.doi.org/10.1016/j.lrr.2023.100370 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chen, Dong
Liu, Guang
Lewis, Michael R.
Li, Xia
Ulrickson, Matthew
Nath, Rajneesh
Chen, Weina
Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
title Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
title_full Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
title_fullStr Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
title_full_unstemmed Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
title_short Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
title_sort myeloid/lymphoid neoplasm with zmym2::fgfr1 rearrangement: a complex trilineage phenotypic and clonal evolution with associated genomic alterations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236454/
https://www.ncbi.nlm.nih.gov/pubmed/37275466
http://dx.doi.org/10.1016/j.lrr.2023.100370
work_keys_str_mv AT chendong myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations
AT liuguang myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations
AT lewismichaelr myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations
AT lixia myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations
AT ulricksonmatthew myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations
AT nathrajneesh myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations
AT chenweina myeloidlymphoidneoplasmwithzmym2fgfr1rearrangementacomplextrilineagephenotypicandclonalevolutionwithassociatedgenomicalterations

Ejemplares similares