Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression

Mitochondria are signaling organelles implicated in cancer, but the mechanisms are elusive. Here, we show that Parkin, an E3 ubiquitination (Ub) ligase altered in Parkinson’s disease, forms a complex with the regulator of cell motility, Kindlin-2 (K2), at mitochondria of tumor cells. In turn, Parkin...

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Detalles Bibliográficos
Autores principales: Yeon, Minjeong, Bertolini, Irene, Agarwal, Ekta, Ghosh, Jagadish C., Tang, Hsin-Yao, Speicher, David W., Keeney, Frederick, Sossey-Alaoui, Khalid, Pluskota, Elzbieta, Bialkowska, Katarzyna, Plow, Edward F., Languino, Lucia R., Skordalakes, Emmanuel, Caino, M. Cecilia, Altieri, Dario C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236456/
https://www.ncbi.nlm.nih.gov/pubmed/37142218
http://dx.doi.org/10.1016/j.jbc.2023.104774

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