Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022

New immune evasive variants of SARS‐CoV‐2 continue to emerge, potentially causing new waves of covid‐19 disease. Here, we evaluate levels of neutralizing antibodies against isolates of Omicron variants, including BQ.1.1 and XBB, in sera harvested 3–4 weeks after vaccination or breakthrough infection...

Descripción completa

Detalles Bibliográficos
Autores principales: Vikse, Elisabeth Lea, Fossum, Even, Erdal, Magnhild Sekse, Hungnes, Olav, Bragstad, Karoline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236499/
https://www.ncbi.nlm.nih.gov/pubmed/37273461
http://dx.doi.org/10.1111/irv.13144
_version_ 1785052939946033152
author Vikse, Elisabeth Lea
Fossum, Even
Erdal, Magnhild Sekse
Hungnes, Olav
Bragstad, Karoline
author_facet Vikse, Elisabeth Lea
Fossum, Even
Erdal, Magnhild Sekse
Hungnes, Olav
Bragstad, Karoline
author_sort Vikse, Elisabeth Lea
collection PubMed
description New immune evasive variants of SARS‐CoV‐2 continue to emerge, potentially causing new waves of covid‐19 disease. Here, we evaluate levels of neutralizing antibodies against isolates of Omicron variants, including BQ.1.1 and XBB, in sera harvested 3–4 weeks after vaccination or breakthrough infections. In addition, we evaluate neutralizing antibodies in 32 sera from October 2022, to evaluate immunity in Norwegian donors prior to the winter season. Most serum samples harvested in October 2022 had low levels of neutralizing antibodies against BQ.1.1 and especially XBB, explaining why these variants and their descendants have dominated in Norway during the 2022 and 2023 winter season.
format Online
Article
Text
id pubmed-10236499
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-102364992023-06-03 Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022 Vikse, Elisabeth Lea Fossum, Even Erdal, Magnhild Sekse Hungnes, Olav Bragstad, Karoline Influenza Other Respir Viruses Short Communications New immune evasive variants of SARS‐CoV‐2 continue to emerge, potentially causing new waves of covid‐19 disease. Here, we evaluate levels of neutralizing antibodies against isolates of Omicron variants, including BQ.1.1 and XBB, in sera harvested 3–4 weeks after vaccination or breakthrough infections. In addition, we evaluate neutralizing antibodies in 32 sera from October 2022, to evaluate immunity in Norwegian donors prior to the winter season. Most serum samples harvested in October 2022 had low levels of neutralizing antibodies against BQ.1.1 and especially XBB, explaining why these variants and their descendants have dominated in Norway during the 2022 and 2023 winter season. John Wiley and Sons Inc. 2023-06-02 /pmc/articles/PMC10236499/ /pubmed/37273461 http://dx.doi.org/10.1111/irv.13144 Text en © 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Vikse, Elisabeth Lea
Fossum, Even
Erdal, Magnhild Sekse
Hungnes, Olav
Bragstad, Karoline
Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022
title Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022
title_full Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022
title_fullStr Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022
title_full_unstemmed Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022
title_short Poor neutralizing antibody responses against SARS‐CoV‐2 Omicron BQ.1.1 and XBB in Norway in October 2022
title_sort poor neutralizing antibody responses against sars‐cov‐2 omicron bq.1.1 and xbb in norway in october 2022
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236499/
https://www.ncbi.nlm.nih.gov/pubmed/37273461
http://dx.doi.org/10.1111/irv.13144
work_keys_str_mv AT vikseelisabethlea poorneutralizingantibodyresponsesagainstsarscov2omicronbq11andxbbinnorwayinoctober2022
AT fossumeven poorneutralizingantibodyresponsesagainstsarscov2omicronbq11andxbbinnorwayinoctober2022
AT erdalmagnhildsekse poorneutralizingantibodyresponsesagainstsarscov2omicronbq11andxbbinnorwayinoctober2022
AT hungnesolav poorneutralizingantibodyresponsesagainstsarscov2omicronbq11andxbbinnorwayinoctober2022
AT bragstadkaroline poorneutralizingantibodyresponsesagainstsarscov2omicronbq11andxbbinnorwayinoctober2022

Ejemplares similares