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Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada

OBJECTIVE: Individuals with Type 2 Diabetes are likely to experience multimorbidity and accumulate multiple chronic conditions over their life. We aimed to identify causes of death and chronic conditions at the time of death in a population-based cohort, and to analyze variations in the presence of...

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Autores principales: Rosella, Laura C., Negatu, Ednah, Kornas, Kathy, Chu, Casey, Zhou, Limei, Buajitti, Emmalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236755/
https://www.ncbi.nlm.nih.gov/pubmed/37264336
http://dx.doi.org/10.1186/s12902-023-01362-x
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author Rosella, Laura C.
Negatu, Ednah
Kornas, Kathy
Chu, Casey
Zhou, Limei
Buajitti, Emmalin
author_facet Rosella, Laura C.
Negatu, Ednah
Kornas, Kathy
Chu, Casey
Zhou, Limei
Buajitti, Emmalin
author_sort Rosella, Laura C.
collection PubMed
description OBJECTIVE: Individuals with Type 2 Diabetes are likely to experience multimorbidity and accumulate multiple chronic conditions over their life. We aimed to identify causes of death and chronic conditions at the time of death in a population-based cohort, and to analyze variations in the presence of diabetes at the time of death overall and across income and immigrant status. RESEARCH DESIGN AND METHODS: We conducted a retrospective cohort study of 2,199,801 adult deaths from 1992 to 2017 in Ontario, Canada. We calculated the proportion of decedents with chronic conditions at time of death and causes of death. The risk of diabetes at the time of death was modeled across sociodemographic variables with a log binomial regression adjusting for sex, age, immigrant status, area-level income. comorbiditiesand time. RESULTS: The leading causes of death in the cohort were cardiovascular and cancer. Decedents with diabetes had a higher prevalence of most chronic conditions than decedents without diabetes, including hypertension, osteo and other arthritis, chronic coronary syndrome, mood disorder, and congestive heart failure. The risk of diabetes at the time of death was 19% higher in immigrants (95%CI 1.18–1.20) and 15% higher in refugees (95%CI 1.12–1.18) compared to long-term residents, and 19% higher in the lowest income quintile (95%CI 1.18–1.20) relative to the highest income quintile, after adjusting for other covariates. CONCLUSIONS: Individuals with diabetes have a greater multimorbidity burden at the time of death, underscoring the importance of multiple chronic disease management among those living with diabetes and further considerations of the social determinants of health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-023-01362-x.
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spelling pubmed-102367552023-06-03 Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada Rosella, Laura C. Negatu, Ednah Kornas, Kathy Chu, Casey Zhou, Limei Buajitti, Emmalin BMC Endocr Disord Research Article OBJECTIVE: Individuals with Type 2 Diabetes are likely to experience multimorbidity and accumulate multiple chronic conditions over their life. We aimed to identify causes of death and chronic conditions at the time of death in a population-based cohort, and to analyze variations in the presence of diabetes at the time of death overall and across income and immigrant status. RESEARCH DESIGN AND METHODS: We conducted a retrospective cohort study of 2,199,801 adult deaths from 1992 to 2017 in Ontario, Canada. We calculated the proportion of decedents with chronic conditions at time of death and causes of death. The risk of diabetes at the time of death was modeled across sociodemographic variables with a log binomial regression adjusting for sex, age, immigrant status, area-level income. comorbiditiesand time. RESULTS: The leading causes of death in the cohort were cardiovascular and cancer. Decedents with diabetes had a higher prevalence of most chronic conditions than decedents without diabetes, including hypertension, osteo and other arthritis, chronic coronary syndrome, mood disorder, and congestive heart failure. The risk of diabetes at the time of death was 19% higher in immigrants (95%CI 1.18–1.20) and 15% higher in refugees (95%CI 1.12–1.18) compared to long-term residents, and 19% higher in the lowest income quintile (95%CI 1.18–1.20) relative to the highest income quintile, after adjusting for other covariates. CONCLUSIONS: Individuals with diabetes have a greater multimorbidity burden at the time of death, underscoring the importance of multiple chronic disease management among those living with diabetes and further considerations of the social determinants of health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-023-01362-x. BioMed Central 2023-06-02 /pmc/articles/PMC10236755/ /pubmed/37264336 http://dx.doi.org/10.1186/s12902-023-01362-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Rosella, Laura C.
Negatu, Ednah
Kornas, Kathy
Chu, Casey
Zhou, Limei
Buajitti, Emmalin
Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
title Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
title_full Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
title_fullStr Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
title_full_unstemmed Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
title_short Multimorbidity at time of death among persons with type 2 diabetes: a population-based study in Ontario, Canada
title_sort multimorbidity at time of death among persons with type 2 diabetes: a population-based study in ontario, canada
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236755/
https://www.ncbi.nlm.nih.gov/pubmed/37264336
http://dx.doi.org/10.1186/s12902-023-01362-x
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