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Current trends in acute pancreatitis: Diagnostic and therapeutic challenges

Acute pancreatitis (AP) is an inflammatory disease of the pancreas, which can progress to severe AP, with a high risk of death. It is one of the most complicated and clinically challenging of all disorders affecting the abdomen. The main causes of AP are gallstone migration and alcohol abuse. Other...

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Autores principales: Zerem, Enver, Kurtcehajic, Admir, Kunosić, Suad, Zerem Malkočević, Dina, Zerem, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237108/
https://www.ncbi.nlm.nih.gov/pubmed/37274068
http://dx.doi.org/10.3748/wjg.v29.i18.2747
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author Zerem, Enver
Kurtcehajic, Admir
Kunosić, Suad
Zerem Malkočević, Dina
Zerem, Omar
author_facet Zerem, Enver
Kurtcehajic, Admir
Kunosić, Suad
Zerem Malkočević, Dina
Zerem, Omar
author_sort Zerem, Enver
collection PubMed
description Acute pancreatitis (AP) is an inflammatory disease of the pancreas, which can progress to severe AP, with a high risk of death. It is one of the most complicated and clinically challenging of all disorders affecting the abdomen. The main causes of AP are gallstone migration and alcohol abuse. Other causes are uncommon, controversial and insufficiently explained. The disease is primarily characterized by inappropriate activation of trypsinogen, infiltration of inflammatory cells, and destruction of secretory cells. According to the revised Atlanta classification, severity of the disease is categorized into three levels: Mild, moderately severe and severe, depending upon organ failure and local as well as systemic complications. Various methods have been used for predicting the severity of AP and its outcome, such as clinical evaluation, imaging evaluation and testing of various biochemical markers. However, AP is a very complex disease and despite the fact that there are of several clinical, biochemical and imaging criteria for assessment of severity of AP, it is not an easy task to predict its subsequent course. Therefore, there are existing controversies regarding diagnostic and therapeutic modalities, their effectiveness and complications in the treatment of AP. The main reason being the fact, that the pathophysiologic mechanisms of AP have not been fully elucidated and need to be studied further. In this editorial article, we discuss the efficacy of the existing diagnostic and therapeutic modalities, complications and treatment failure in the management of AP.
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spelling pubmed-102371082023-06-03 Current trends in acute pancreatitis: Diagnostic and therapeutic challenges Zerem, Enver Kurtcehajic, Admir Kunosić, Suad Zerem Malkočević, Dina Zerem, Omar World J Gastroenterol Review Acute pancreatitis (AP) is an inflammatory disease of the pancreas, which can progress to severe AP, with a high risk of death. It is one of the most complicated and clinically challenging of all disorders affecting the abdomen. The main causes of AP are gallstone migration and alcohol abuse. Other causes are uncommon, controversial and insufficiently explained. The disease is primarily characterized by inappropriate activation of trypsinogen, infiltration of inflammatory cells, and destruction of secretory cells. According to the revised Atlanta classification, severity of the disease is categorized into three levels: Mild, moderately severe and severe, depending upon organ failure and local as well as systemic complications. Various methods have been used for predicting the severity of AP and its outcome, such as clinical evaluation, imaging evaluation and testing of various biochemical markers. However, AP is a very complex disease and despite the fact that there are of several clinical, biochemical and imaging criteria for assessment of severity of AP, it is not an easy task to predict its subsequent course. Therefore, there are existing controversies regarding diagnostic and therapeutic modalities, their effectiveness and complications in the treatment of AP. The main reason being the fact, that the pathophysiologic mechanisms of AP have not been fully elucidated and need to be studied further. In this editorial article, we discuss the efficacy of the existing diagnostic and therapeutic modalities, complications and treatment failure in the management of AP. Baishideng Publishing Group Inc 2023-05-14 2023-05-14 /pmc/articles/PMC10237108/ /pubmed/37274068 http://dx.doi.org/10.3748/wjg.v29.i18.2747 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Zerem, Enver
Kurtcehajic, Admir
Kunosić, Suad
Zerem Malkočević, Dina
Zerem, Omar
Current trends in acute pancreatitis: Diagnostic and therapeutic challenges
title Current trends in acute pancreatitis: Diagnostic and therapeutic challenges
title_full Current trends in acute pancreatitis: Diagnostic and therapeutic challenges
title_fullStr Current trends in acute pancreatitis: Diagnostic and therapeutic challenges
title_full_unstemmed Current trends in acute pancreatitis: Diagnostic and therapeutic challenges
title_short Current trends in acute pancreatitis: Diagnostic and therapeutic challenges
title_sort current trends in acute pancreatitis: diagnostic and therapeutic challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237108/
https://www.ncbi.nlm.nih.gov/pubmed/37274068
http://dx.doi.org/10.3748/wjg.v29.i18.2747
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