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Development of abnormalities at the neuromuscular junction in the SOD1-G93A mouse model of ALS: dysfunction then disruption of postsynaptic structure precede overt motor symptoms

INTRODUCTION: The ultimate deficit in amyotrophic lateral sclerosis (ALS) is neuromuscular junction (NMJ) loss, producing permanent paralysis, ultimately in respiratory muscles. However, understanding the functional and structural deficits at NMJs prior to this loss is crucial for therapeutic strate...

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Detalles Bibliográficos
Autores principales:	McIntosh, Jayne, Mekrouda, Imane, Dashti, Maryam, Giuraniuc, Claudiu V., Banks, Robert W., Miles, Gareth B., Bewick, Guy S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237339/ https://www.ncbi.nlm.nih.gov/pubmed/37273905 http://dx.doi.org/10.3389/fnmol.2023.1169075

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