Targeting the IL4 receptor with MDNA55 in patients with recurrent glioblastoma: Results of a phase IIb trial

BACKGROUND: MDNA55 is an interleukin 4 receptor (IL4R)-targeting toxin in development for recurrent GBM, a universally fatal disease. IL4R is overexpressed in GBM as well as cells of the tumor microenvironment. High expression of IL4R is associated with poor clinical outcomes. METHODS: MDNA55-05 is...

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Detalles Bibliográficos
Autores principales: Sampson, John H, Singh Achrol, Achal, Aghi, Manish K, Bankiewicz, Krystof, Bexon, Martin, Brem, Steven, Brenner, Andrew, Chandhasin, Chandtip, Chowdhary, Sajeel, Coello, Melissa, Ellingson, Benjamin M, Floyd, John R, Han, Seunggu, Kesari, Santosh, Mardor, Yael, Merchant, Fahar, Merchant, Nina, Randazzo, Dina, Vogelbaum, Michael, Vrionis, Frank, Wembacher-Schroeder, Eva, Zabek, Miroslaw, Butowski, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237418/
https://www.ncbi.nlm.nih.gov/pubmed/36640127
http://dx.doi.org/10.1093/neuonc/noac285

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