Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival

Durable objective response rate (ORR) remains a meaningful endpoint in recurrent cancer; however, the target ORR for single-arm recurrent glioblastoma trials has not been based on historic information or tied to patient outcomes. The current study reviewed 68 treatment arms comprising 4793 patients...

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Detalles Bibliográficos
Autores principales: Ellingson, Benjamin M, Wen, Patrick Y, Chang, Susan M, van den Bent, Martin, Vogelbaum, Michael A, Li, Gang, Li, Shanpeng, Kim, Jiyoon, Youssef, Gilbert, Wick, Wolfgang, Lassman, Andrew B, Gilbert, Mark R, de Groot, John F, Weller, Michael, Galanis, Evanthia, Cloughesy, Timothy F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237425/
https://www.ncbi.nlm.nih.gov/pubmed/36617262
http://dx.doi.org/10.1093/neuonc/noad002

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