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Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain

Previous literature suggests that a balance between Pavlovian and instrumental decision-making systems is critical for optimal decision-making. Pavlovian bias (i.e., approach toward reward-predictive stimuli and avoid punishment-predictive stimuli) often contrasts with the instrumental response. Alt...

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Autores principales: Kim, Hyeonjin, Hur, Jihyun K., Kwon, Mina, Kim, Soyeon, Zoh, Yoonseo, Ahn, Woo-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237433/
https://www.ncbi.nlm.nih.gov/pubmed/37267307
http://dx.doi.org/10.1371/journal.pone.0286632
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author Kim, Hyeonjin
Hur, Jihyun K.
Kwon, Mina
Kim, Soyeon
Zoh, Yoonseo
Ahn, Woo-Young
author_facet Kim, Hyeonjin
Hur, Jihyun K.
Kwon, Mina
Kim, Soyeon
Zoh, Yoonseo
Ahn, Woo-Young
author_sort Kim, Hyeonjin
collection PubMed
description Previous literature suggests that a balance between Pavlovian and instrumental decision-making systems is critical for optimal decision-making. Pavlovian bias (i.e., approach toward reward-predictive stimuli and avoid punishment-predictive stimuli) often contrasts with the instrumental response. Although recent neuroimaging studies have identified brain regions that may be related to Pavlovian bias, including the dorsolateral prefrontal cortex (dlPFC), it is unclear whether a causal relationship exists. Therefore, we investigated whether upregulation of the dlPFC using transcranial current direct stimulation (tDCS) would reduce Pavlovian bias. In this double-blind study, participants were assigned to the anodal or the sham group; they received stimulation over the right dlPFC for 3 successive days. On the last day, participants performed a reinforcement learning task known as the orthogonalized go/no-go task; this was used to assess each participant’s degree of Pavlovian bias in reward and punishment domains. We used computational modeling and hierarchical Bayesian analysis to estimate model parameters reflecting latent cognitive processes, including Pavlovian bias, go bias, and choice randomness. Several computational models were compared; the model with separate Pavlovian bias parameters for reward and punishment domains demonstrated the best model fit. When using a behavioral index of Pavlovian bias, the anodal group showed significantly lower Pavlovian bias in the punishment domain, but not in the reward domain, compared with the sham group. In addition, computational modeling showed that Pavlovian bias parameter in the punishment domain was lower in the anodal group than in the sham group, which is consistent with the behavioral findings. The anodal group also showed a lower go bias and choice randomness, compared with the sham group. These findings suggest that anodal tDCS may lead to behavioral suppression or change in Pavlovian bias in the punishment domain, which will help to improve comprehension of the causal neural mechanism.
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spelling pubmed-102374332023-06-03 Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain Kim, Hyeonjin Hur, Jihyun K. Kwon, Mina Kim, Soyeon Zoh, Yoonseo Ahn, Woo-Young PLoS One Research Article Previous literature suggests that a balance between Pavlovian and instrumental decision-making systems is critical for optimal decision-making. Pavlovian bias (i.e., approach toward reward-predictive stimuli and avoid punishment-predictive stimuli) often contrasts with the instrumental response. Although recent neuroimaging studies have identified brain regions that may be related to Pavlovian bias, including the dorsolateral prefrontal cortex (dlPFC), it is unclear whether a causal relationship exists. Therefore, we investigated whether upregulation of the dlPFC using transcranial current direct stimulation (tDCS) would reduce Pavlovian bias. In this double-blind study, participants were assigned to the anodal or the sham group; they received stimulation over the right dlPFC for 3 successive days. On the last day, participants performed a reinforcement learning task known as the orthogonalized go/no-go task; this was used to assess each participant’s degree of Pavlovian bias in reward and punishment domains. We used computational modeling and hierarchical Bayesian analysis to estimate model parameters reflecting latent cognitive processes, including Pavlovian bias, go bias, and choice randomness. Several computational models were compared; the model with separate Pavlovian bias parameters for reward and punishment domains demonstrated the best model fit. When using a behavioral index of Pavlovian bias, the anodal group showed significantly lower Pavlovian bias in the punishment domain, but not in the reward domain, compared with the sham group. In addition, computational modeling showed that Pavlovian bias parameter in the punishment domain was lower in the anodal group than in the sham group, which is consistent with the behavioral findings. The anodal group also showed a lower go bias and choice randomness, compared with the sham group. These findings suggest that anodal tDCS may lead to behavioral suppression or change in Pavlovian bias in the punishment domain, which will help to improve comprehension of the causal neural mechanism. Public Library of Science 2023-06-02 /pmc/articles/PMC10237433/ /pubmed/37267307 http://dx.doi.org/10.1371/journal.pone.0286632 Text en © 2023 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Hyeonjin
Hur, Jihyun K.
Kwon, Mina
Kim, Soyeon
Zoh, Yoonseo
Ahn, Woo-Young
Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
title Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
title_full Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
title_fullStr Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
title_full_unstemmed Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
title_short Causal role of the dorsolateral prefrontal cortex in modulating the balance between Pavlovian and instrumental systems in the punishment domain
title_sort causal role of the dorsolateral prefrontal cortex in modulating the balance between pavlovian and instrumental systems in the punishment domain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237433/
https://www.ncbi.nlm.nih.gov/pubmed/37267307
http://dx.doi.org/10.1371/journal.pone.0286632
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