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Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth

BACKGROUND: High-grade gliomas are malignant brain tumors characterized by aggressiveness and resistance to chemotherapy. Prognosis remains dismal, highlighting the need to identify novel molecular dependencies and targets. Ribosome biogenesis (RiBi), taking place in the nucleolus, represents a prom...

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Detalles Bibliográficos
Autores principales:	Zisi, Asimina, Kanellis, Dimitris C, Moussaud, Simon, Karlsson, Ida, Carén, Helena, Bräutigam, Lars, Bartek, Jiri, Lindström, Mikael S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237440/ https://www.ncbi.nlm.nih.gov/pubmed/36583853 http://dx.doi.org/10.1093/neuonc/noac286

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