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Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging

Brown adipose tissue (BAT)-mediated thermogenesis declines with age. However, the underlying mechanism remains unclear. Here we reveal that bone marrow-derived pro-inflammatory and senescent S100A8(+) immune cells, mainly T cells and neutrophils, invade the BAT of male rats and mice during aging. Th...

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Detalles Bibliográficos
Autores principales:	Feng, Xu, Wang, Liwen, Zhou, Ruoyu, Zhou, Rui, Chen, Linyun, Peng, Hui, Huang, Yan, Guo, Qi, Luo, Xianghang, Zhou, Haiyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237528/ https://www.ncbi.nlm.nih.gov/pubmed/37268694 http://dx.doi.org/10.1038/s41467-023-38842-6

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