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Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits

It remains unknown to what extent gene-gene interactions contribute to complex traits. Here, we introduce a new approach using predicted gene expression to perform exhaustive transcriptome-wide interaction studies (TWISs) for multiple traits across all pairs of genes expressed in several tissue type...

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Detalles Bibliográficos
Autores principales:	Evans, Luke M., Arehart, Christopher H., Grotzinger, Andrew D., Mize, Travis J., Brasher, Maizy S., Stitzel, Jerry A., Ehringer, Marissa A., Hoeffer, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237671/ https://www.ncbi.nlm.nih.gov/pubmed/37216417 http://dx.doi.org/10.1371/journal.pgen.1010693

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