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Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study

Fracture is a global public health disease. Bone health and fracture risk have become the focus of public and scientific attention. Observational studies have reported that tea consumption is associated with fracture risk, but the results are inconsistent. The present study used 2-sample Mendelian r...

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Autores principales: Pu, Bin, Gu, Peng, Luo, Lieliang, Yue, Dan, Xin, Qiao, Zeng, Zhanpeng, Zheng, Xiaohui, Luo, WeiDong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238023/
https://www.ncbi.nlm.nih.gov/pubmed/37266651
http://dx.doi.org/10.1097/MD.0000000000033542
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author Pu, Bin
Gu, Peng
Luo, Lieliang
Yue, Dan
Xin, Qiao
Zeng, Zhanpeng
Zheng, Xiaohui
Luo, WeiDong
author_facet Pu, Bin
Gu, Peng
Luo, Lieliang
Yue, Dan
Xin, Qiao
Zeng, Zhanpeng
Zheng, Xiaohui
Luo, WeiDong
author_sort Pu, Bin
collection PubMed
description Fracture is a global public health disease. Bone health and fracture risk have become the focus of public and scientific attention. Observational studies have reported that tea consumption is associated with fracture risk, but the results are inconsistent. The present study used 2-sample Mendelian randomization (MR) analysis. The inverse variance weighted method, employing genetic data from UK Biobank (447,485 cases) of tea intake and UK Biobank (Genome-wide association study Round 2) project (361,194 cases) of fractures, was performed to estimate the causal relationship between tea intake and multiple types of fractures. The inverse variance weighted indicated no causal effects of tea consumption on fractures of the skull and face, shoulder and upper arm, hand and wrist, femur, calf, and ankle (odds ratio = 1.000, 1.000, 1.002, 0.997, 0.998; P = .881, 0.857, 0.339, 0.054, 0.569, respectively). Consistent results were also found in MR-Egger, weighted median, and weighted mode. Our research provided evidence that tea consumption is unlikely to affect the incidence of fractures.
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spelling pubmed-102380232023-06-03 Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study Pu, Bin Gu, Peng Luo, Lieliang Yue, Dan Xin, Qiao Zeng, Zhanpeng Zheng, Xiaohui Luo, WeiDong Medicine (Baltimore) 5500 Fracture is a global public health disease. Bone health and fracture risk have become the focus of public and scientific attention. Observational studies have reported that tea consumption is associated with fracture risk, but the results are inconsistent. The present study used 2-sample Mendelian randomization (MR) analysis. The inverse variance weighted method, employing genetic data from UK Biobank (447,485 cases) of tea intake and UK Biobank (Genome-wide association study Round 2) project (361,194 cases) of fractures, was performed to estimate the causal relationship between tea intake and multiple types of fractures. The inverse variance weighted indicated no causal effects of tea consumption on fractures of the skull and face, shoulder and upper arm, hand and wrist, femur, calf, and ankle (odds ratio = 1.000, 1.000, 1.002, 0.997, 0.998; P = .881, 0.857, 0.339, 0.054, 0.569, respectively). Consistent results were also found in MR-Egger, weighted median, and weighted mode. Our research provided evidence that tea consumption is unlikely to affect the incidence of fractures. Lippincott Williams & Wilkins 2023-06-02 /pmc/articles/PMC10238023/ /pubmed/37266651 http://dx.doi.org/10.1097/MD.0000000000033542 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5500
Pu, Bin
Gu, Peng
Luo, Lieliang
Yue, Dan
Xin, Qiao
Zeng, Zhanpeng
Zheng, Xiaohui
Luo, WeiDong
Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study
title Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study
title_full Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study
title_fullStr Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study
title_full_unstemmed Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study
title_short Causal effects of tea intake on multiple types of fractures: A two-sample Mendelian randomization study
title_sort causal effects of tea intake on multiple types of fractures: a two-sample mendelian randomization study
topic 5500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238023/
https://www.ncbi.nlm.nih.gov/pubmed/37266651
http://dx.doi.org/10.1097/MD.0000000000033542
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