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Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study

This study aimed to investigate the associations between hepatitis virus infection and inpatient outcomes of acute pancreatitis (AP). In this population-based, retrospective study, hospitalized patients with AP were identified in the 2005 to 2018 United States Nationwide Inpatient Sample database. U...

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Autores principales: Lai, Hsin-Wu, Hung, Hung-Chang, Lin, Chun-Che
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238054/
https://www.ncbi.nlm.nih.gov/pubmed/37266621
http://dx.doi.org/10.1097/MD.0000000000033952
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author Lai, Hsin-Wu
Hung, Hung-Chang
Lin, Chun-Che
author_facet Lai, Hsin-Wu
Hung, Hung-Chang
Lin, Chun-Che
author_sort Lai, Hsin-Wu
collection PubMed
description This study aimed to investigate the associations between hepatitis virus infection and inpatient outcomes of acute pancreatitis (AP). In this population-based, retrospective study, hospitalized patients with AP were identified in the 2005 to 2018 United States Nationwide Inpatient Sample database. Univariate and multivariable regression analyses were conducted to evaluate the associations between hepatitis virus infection, death/discharge against medical advice (DAMA), prolonged length of stay (LOS), and occurrence of life-threatening complications including ischemia/infarction of the intestine, portal vein thrombosis, acute organ failure, systemic inflammatory response syndrome, and hypovolemic shock. A total of 775,416 patients hospitalized for AP comprised the analytic cohort. Amongst, 26,407 subjects (3.4%) had been diagnosed hepatitis virus infection, whereas 749,009 (96.6%) had not. Mean age of the subjects was 51.4 years. After adjusting for relevant confounders, hepatitis virus infection was significantly and independently associated with increased odds of death/DAMA (aOR = 1.33, 95% CI = 1.26–1.40), prolonged LOS (aOR = 1.12, 95%CI = 1.09–1.16), and acute organ failure (aOR = 1.06, 95% CI = 1.01–1.12). In patients with AP, hepatitis virus infection is an independent predictor of worse inpatient outcomes in terms of more death/DAMA, prolonged LOS, and life-threatening complications. The findings may help risk stratification and the development of proper strategies for managing patients suffered from AP.
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spelling pubmed-102380542023-06-03 Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study Lai, Hsin-Wu Hung, Hung-Chang Lin, Chun-Che Medicine (Baltimore) 4500 This study aimed to investigate the associations between hepatitis virus infection and inpatient outcomes of acute pancreatitis (AP). In this population-based, retrospective study, hospitalized patients with AP were identified in the 2005 to 2018 United States Nationwide Inpatient Sample database. Univariate and multivariable regression analyses were conducted to evaluate the associations between hepatitis virus infection, death/discharge against medical advice (DAMA), prolonged length of stay (LOS), and occurrence of life-threatening complications including ischemia/infarction of the intestine, portal vein thrombosis, acute organ failure, systemic inflammatory response syndrome, and hypovolemic shock. A total of 775,416 patients hospitalized for AP comprised the analytic cohort. Amongst, 26,407 subjects (3.4%) had been diagnosed hepatitis virus infection, whereas 749,009 (96.6%) had not. Mean age of the subjects was 51.4 years. After adjusting for relevant confounders, hepatitis virus infection was significantly and independently associated with increased odds of death/DAMA (aOR = 1.33, 95% CI = 1.26–1.40), prolonged LOS (aOR = 1.12, 95%CI = 1.09–1.16), and acute organ failure (aOR = 1.06, 95% CI = 1.01–1.12). In patients with AP, hepatitis virus infection is an independent predictor of worse inpatient outcomes in terms of more death/DAMA, prolonged LOS, and life-threatening complications. The findings may help risk stratification and the development of proper strategies for managing patients suffered from AP. Lippincott Williams & Wilkins 2023-06-02 /pmc/articles/PMC10238054/ /pubmed/37266621 http://dx.doi.org/10.1097/MD.0000000000033952 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 4500
Lai, Hsin-Wu
Hung, Hung-Chang
Lin, Chun-Che
Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study
title Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study
title_full Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study
title_fullStr Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study
title_full_unstemmed Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study
title_short Impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: A population-based study
title_sort impact of hepatitis virus infection on inpatient outcomes of acute pancreatitis: a population-based study
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238054/
https://www.ncbi.nlm.nih.gov/pubmed/37266621
http://dx.doi.org/10.1097/MD.0000000000033952
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