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Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors

The effect of mutations of the catalytic dyad residues of SARS-CoV-2 main protease (MPro(WT)) on the thermodynamics of binding of covalent inhibitors comprising nitrile [nirmatrelvir (NMV), NBH2], aldehyde (GC373), and ketone (BBH1) warheads to MPro is examined together with room temperature X-ray c...

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Detalles Bibliográficos
Autores principales:	Kovalevsky, Andrey, Aniana, Annie, Coates, Leighton, Bonnesen, Peter V., Nashed, Nashaat T., Louis, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238122/ https://www.ncbi.nlm.nih.gov/pubmed/37271339 http://dx.doi.org/10.1016/j.jbc.2023.104886

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