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Pharmacological Effects of Genistein on Cardiovascular Diseases

Cardiovascular diseases (CVDs) are a group of disorders that involve the heart or blood vessels and are the leading cause of mortality worldwide. Natural products have several pharmacological activities, such as anti-inflammatory, antioxidant, and immunoregulatory properties. This review summarizes...

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Autores principales: Jafari, Shima, Shoghi, Melika, Khazdair, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238142/
https://www.ncbi.nlm.nih.gov/pubmed/37275572
http://dx.doi.org/10.1155/2023/8250219
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author Jafari, Shima
Shoghi, Melika
Khazdair, Mohammad Reza
author_facet Jafari, Shima
Shoghi, Melika
Khazdair, Mohammad Reza
author_sort Jafari, Shima
collection PubMed
description Cardiovascular diseases (CVDs) are a group of disorders that involve the heart or blood vessels and are the leading cause of mortality worldwide. Natural products have several pharmacological activities, such as anti-inflammatory, antioxidant, and immunoregulatory properties. This review summarizes the possible therapeutic effects of Genistein on CVD. The information from the current review study was obtained by searching for the keywords such as “Genistein”, “Cardiac dysfunction”, “hypertrophy”, and “Ischemia” “lipid profile” in different online database such as PubMed, Scopus, and Google Scholar, until February 2022. The results of the studies showed that genistein intake has a promising effect on improving cardiac dysfunction, ischemia, and reperfusion of the heart, decreasing cardiac toxicity, modulating lipid profile, and lowering blood pressure. The preventive effects of genistein on experimental models of studies were shown through mechanisms such as anti-inflammatory, antioxidant, and immunomodulatory effects. Pharmacological effects of genistein on cardiac dysfunction, cardiac toxicity, lipid profile, and hypertension indicate the possible remedy effect of this agent in the treatment of CVD.
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spelling pubmed-102381422023-06-03 Pharmacological Effects of Genistein on Cardiovascular Diseases Jafari, Shima Shoghi, Melika Khazdair, Mohammad Reza Evid Based Complement Alternat Med Review Article Cardiovascular diseases (CVDs) are a group of disorders that involve the heart or blood vessels and are the leading cause of mortality worldwide. Natural products have several pharmacological activities, such as anti-inflammatory, antioxidant, and immunoregulatory properties. This review summarizes the possible therapeutic effects of Genistein on CVD. The information from the current review study was obtained by searching for the keywords such as “Genistein”, “Cardiac dysfunction”, “hypertrophy”, and “Ischemia” “lipid profile” in different online database such as PubMed, Scopus, and Google Scholar, until February 2022. The results of the studies showed that genistein intake has a promising effect on improving cardiac dysfunction, ischemia, and reperfusion of the heart, decreasing cardiac toxicity, modulating lipid profile, and lowering blood pressure. The preventive effects of genistein on experimental models of studies were shown through mechanisms such as anti-inflammatory, antioxidant, and immunomodulatory effects. Pharmacological effects of genistein on cardiac dysfunction, cardiac toxicity, lipid profile, and hypertension indicate the possible remedy effect of this agent in the treatment of CVD. Hindawi 2023-05-26 /pmc/articles/PMC10238142/ /pubmed/37275572 http://dx.doi.org/10.1155/2023/8250219 Text en Copyright © 2023 Shima Jafari et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jafari, Shima
Shoghi, Melika
Khazdair, Mohammad Reza
Pharmacological Effects of Genistein on Cardiovascular Diseases
title Pharmacological Effects of Genistein on Cardiovascular Diseases
title_full Pharmacological Effects of Genistein on Cardiovascular Diseases
title_fullStr Pharmacological Effects of Genistein on Cardiovascular Diseases
title_full_unstemmed Pharmacological Effects of Genistein on Cardiovascular Diseases
title_short Pharmacological Effects of Genistein on Cardiovascular Diseases
title_sort pharmacological effects of genistein on cardiovascular diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238142/
https://www.ncbi.nlm.nih.gov/pubmed/37275572
http://dx.doi.org/10.1155/2023/8250219
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