Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023)

Biofabricate Lung Tumors In article number 2206603 by Mien‐Chie Hung, Der‐Yang Cho, Yi‐Wen Chen, and co‐workers, a facile route to construct sophisticated ex vivo lung tumors models consisting of patientderived tumor spheroids, vasculature barrier, and bovine lung ECMs, which maintained a radial oxy...

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Detalles Bibliográficos
Autores principales: Shie, Ming‐You, Fang, Hsin‐Yuan, Kan, Kai‐Wen, Ho, Chia‐Che, Tu, Chih‐Yen, Lee, Pei‐Chih, Hsueh, Po‐Ren, Chen, Chia‐Hung, Lee, Alvin Kai‐Xing, Tien, Ni, Chen, Jian‐Xun, Shen, Yu‐Cheng, Chang, Jan‐Gowth, Shen, Yu‐Fang, Lin, Ting‐Ju, Wang, Ben, Hung, Mien‐Chie, Cho, Der‐Yang, Chen, Yi‐Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238182/
http://dx.doi.org/10.1002/advs.202370101
Descripción
Sumario:Biofabricate Lung Tumors In article number 2206603 by Mien‐Chie Hung, Der‐Yang Cho, Yi‐Wen Chen, and co‐workers, a facile route to construct sophisticated ex vivo lung tumors models consisting of patientderived tumor spheroids, vasculature barrier, and bovine lung ECMs, which maintained a radial oxygen gradient, as well as biophysical and biochemical behaviors of the native tumors is established. This model demonstrates the excellent prediction results (accuracy: 85%; sensitivity: 86.7% and specificity: 80%) for applying in patient‐specific precision therapies. [Image: see text]

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