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Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023)
Biofabricate Lung Tumors In article number 2206603 by Mien‐Chie Hung, Der‐Yang Cho, Yi‐Wen Chen, and co‐workers, a facile route to construct sophisticated ex vivo lung tumors models consisting of patientderived tumor spheroids, vasculature barrier, and bovine lung ECMs, which maintained a radial oxy...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238182/ http://dx.doi.org/10.1002/advs.202370101 |
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author | Shie, Ming‐You Fang, Hsin‐Yuan Kan, Kai‐Wen Ho, Chia‐Che Tu, Chih‐Yen Lee, Pei‐Chih Hsueh, Po‐Ren Chen, Chia‐Hung Lee, Alvin Kai‐Xing Tien, Ni Chen, Jian‐Xun Shen, Yu‐Cheng Chang, Jan‐Gowth Shen, Yu‐Fang Lin, Ting‐Ju Wang, Ben Hung, Mien‐Chie Cho, Der‐Yang Chen, Yi‐Wen |
author_facet | Shie, Ming‐You Fang, Hsin‐Yuan Kan, Kai‐Wen Ho, Chia‐Che Tu, Chih‐Yen Lee, Pei‐Chih Hsueh, Po‐Ren Chen, Chia‐Hung Lee, Alvin Kai‐Xing Tien, Ni Chen, Jian‐Xun Shen, Yu‐Cheng Chang, Jan‐Gowth Shen, Yu‐Fang Lin, Ting‐Ju Wang, Ben Hung, Mien‐Chie Cho, Der‐Yang Chen, Yi‐Wen |
author_sort | Shie, Ming‐You |
collection | PubMed |
description | Biofabricate Lung Tumors In article number 2206603 by Mien‐Chie Hung, Der‐Yang Cho, Yi‐Wen Chen, and co‐workers, a facile route to construct sophisticated ex vivo lung tumors models consisting of patientderived tumor spheroids, vasculature barrier, and bovine lung ECMs, which maintained a radial oxygen gradient, as well as biophysical and biochemical behaviors of the native tumors is established. This model demonstrates the excellent prediction results (accuracy: 85%; sensitivity: 86.7% and specificity: 80%) for applying in patient‐specific precision therapies. [Image: see text] |
format | Online Article Text |
id | pubmed-10238182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102381822023-06-04 Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) Shie, Ming‐You Fang, Hsin‐Yuan Kan, Kai‐Wen Ho, Chia‐Che Tu, Chih‐Yen Lee, Pei‐Chih Hsueh, Po‐Ren Chen, Chia‐Hung Lee, Alvin Kai‐Xing Tien, Ni Chen, Jian‐Xun Shen, Yu‐Cheng Chang, Jan‐Gowth Shen, Yu‐Fang Lin, Ting‐Ju Wang, Ben Hung, Mien‐Chie Cho, Der‐Yang Chen, Yi‐Wen Adv Sci (Weinh) Frontispiece Biofabricate Lung Tumors In article number 2206603 by Mien‐Chie Hung, Der‐Yang Cho, Yi‐Wen Chen, and co‐workers, a facile route to construct sophisticated ex vivo lung tumors models consisting of patientderived tumor spheroids, vasculature barrier, and bovine lung ECMs, which maintained a radial oxygen gradient, as well as biophysical and biochemical behaviors of the native tumors is established. This model demonstrates the excellent prediction results (accuracy: 85%; sensitivity: 86.7% and specificity: 80%) for applying in patient‐specific precision therapies. [Image: see text] John Wiley and Sons Inc. 2023-06-02 /pmc/articles/PMC10238182/ http://dx.doi.org/10.1002/advs.202370101 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Frontispiece Shie, Ming‐You Fang, Hsin‐Yuan Kan, Kai‐Wen Ho, Chia‐Che Tu, Chih‐Yen Lee, Pei‐Chih Hsueh, Po‐Ren Chen, Chia‐Hung Lee, Alvin Kai‐Xing Tien, Ni Chen, Jian‐Xun Shen, Yu‐Cheng Chang, Jan‐Gowth Shen, Yu‐Fang Lin, Ting‐Ju Wang, Ben Hung, Mien‐Chie Cho, Der‐Yang Chen, Yi‐Wen Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) |
title | Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) |
title_full | Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) |
title_fullStr | Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) |
title_full_unstemmed | Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) |
title_short | Highly Mimetic Ex Vivo Lung‐Cancer Spheroid‐Based Physiological Model for Clinical Precision Therapeutics (Adv. Sci. 16/2023) |
title_sort | highly mimetic ex vivo lung‐cancer spheroid‐based physiological model for clinical precision therapeutics (adv. sci. 16/2023) |
topic | Frontispiece |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238182/ http://dx.doi.org/10.1002/advs.202370101 |
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