Cargando…

Integrative Single‐Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics

The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single‐cell RNA sequencing and single‐cell assay for transposase‐accessible chromatin sequencing are performed on human embryonic eye samples obtained 9–26 weeks after...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ruonan, Liu, Jiangyi, Yi, Ping, Yang, Xianli, Chen, Jun, Zhao, Chenyang, Liao, Xingyun, Wang, Xiaotang, Xu, Zongren, Lu, Huiping, Li, Hongshun, Zhang, Zhi, Liu, Xianyang, Xiang, Junjie, Hu, Ke, Qi, Hongbo, Yu, Jia, Yang, Peizeng, Hou, Shengping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238188/ https://www.ncbi.nlm.nih.gov/pubmed/37017569 http://dx.doi.org/10.1002/advs.202206623

Ejemplares similares

A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing
por: Liu, Xianyang, et al.
Publicado: (2023)

A Single-Cell Transcriptome Atlas of the Human Retinal Pigment Epithelium
por: Xu, Zongren, et al.
Publicado: (2021)

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia
por: Zhao, Chenyang, et al.
Publicado: (2022)

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization
por: Wang, Guoqing, et al.
Publicado: (2022)

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization
por: Shu, Nan, et al.
Publicado: (2023)

SOX2‐positive retinal stem cells are identified in adult human pars plicata by single‐cell transcriptomic analyses
por: Wang, Xiaotang, et al.
Publicado: (2022)

Global lactylome reveals lactylation-dependent mechanisms underlying T(H)17 differentiation in experimental autoimmune uveitis
por: Fan, Wei, et al.
Publicado: (2023)

Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA
por: Zhou, Hongxiu, et al.
Publicado: (2021)

The Circular RNome of Developmental Retina in Mice
por: Chen, Xue-Jiao, et al.
Publicado: (2019)

Epigenomic programming in early fetal brain development
por: Li, Luolan, et al.
Publicado: (2020)

METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m(6)A-dependent manner
por: Meng, Jiayu, et al.
Publicado: (2022)

Developmental Epigenetics: Phenotype and the Flexible Epigenome
por: John, Rosalind M., et al.
Publicado: (2018)

Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns
por: Zhu, Hong, et al.
Publicado: (2023)

Developmental errors in the common marmoset retina
por: Haverkamp, Silke, et al.
Publicado: (2022)

Targeting the epigenome in in-stent restenosis: from mechanisms to therapy
por: Yang, Xi, et al.
Publicado: (2021)

Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution
por: Li, Li, et al.
Publicado: (2020)

Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4(+) T Cells from Patients with Vogt-Koyanagi-Harada Syndrome
por: Mao, Liming, et al.
Publicado: (2011)

Lack of association of two polymorphisms of IRF5 with Behcet’s disease
por: Li, Haijun, et al.
Publicado: (2009)

Correction: Label-Free Proteomics Reveals Decreased Expression of CD18 and AKNA in Peripheral CD4(+) T Cells from Patients with Vogt-Koyanagi-Harada Syndrome
por: Mao, Liming, et al.
Publicado: (2011)

Association of TNFSF4 Polymorphisms with Vogt-Koyanagi-Harada and Behcet’s Disease in Han Chinese
por: Lu, Sha, et al.
Publicado: (2016)

The developmental regulation of CD81 in the rat retina
por: Pan, Ye, et al.
Publicado: (2007)

Localization and Developmental Expression Patterns of CSPG in the RCS Rat Retina
por: Chen, Li-Feng, et al.
Publicado: (2011)

Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective
por: Quinn, Peter M.J., et al.
Publicado: (2019)

High-Salt Enhances the Inflammatory Response by Retina Pigment Epithelium Cells following Lipopolysaccharide Stimulation
por: Zhang, Dike, et al.
Publicado: (2015)

Disabled-1 Alternative Splicing in Human Fetal Retina and Neural Tumors
por: Katyal, Sachin, et al.
Publicado: (2011)

Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome
por: Chango, Abalo, et al.
Publicado: (2015)

Four Dimensions of the Cardiac Myocyte Epigenome: from Fetal to Adult Heart
por: Rommel, Carolin, et al.
Publicado: (2020)

Hagfish to Illuminate the Developmental and Evolutionary Origins of the Vertebrate Retina
por: Bradshaw, Sarah N., et al.
Publicado: (2022)

Association between polymorphisms of FCRL3, a non-HLA gene, and Behçet’s disease in a Chinese population with ophthalmic manifestations
por: Li, Ke, et al.
Publicado: (2008)

TNFAIP3 Gene Polymorphisms in a Chinese Han Population with Vogt–Koyanagi–Harada Syndrome
por: Li, Hong, et al.
Publicado: (2013)

Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population
por: Rizzo, Heather E., et al.
Publicado: (2020)

Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin
por: Zibetti, Cristina, et al.
Publicado: (2019)

Leveraging biological and statistical covariates improves the detection power in epigenome-wide association testing
por: Huang, Jinyan, et al.
Publicado: (2020)

Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism
por: Feng, Yayan, et al.
Publicado: (2021)

Central and Peripheral Retina Arise through Distinct Developmental Paths
por: Venters, Sara J., et al.
Publicado: (2013)

Small ubiquitin-like modifier 4 (SUMO4) polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population
por: Hou, Shengping, et al.
Publicado: (2008)

PDCD1 genes may protect against extraocular manifestations in Chinese Han patients with Vogt-Koyanagi-Harada syndrome
por: Meng, Qianli, et al.
Publicado: (2009)

Distinct epigenomic patterns are associated with haploinsufficiency and predict risk genes of developmental disorders
por: Han, Xinwei, et al.
Publicado: (2018)

Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
por: Gerrard, Dave T., et al.
Publicado: (2020)

Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome
por: Lin, Xinyi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_f3393rjfeqtt5a9j7ram1m7s08