Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain

Adaptor protein 2-associated kinase 1 (AAK1) is a member of the Ark1/Prk1 family of serine/threonine kinases and plays a role in modulating receptor endocytosis. AAK1 was identified as a potential therapeutic target for the treatment of neuropathic pain when it was shown that AAK1 knock out (KO) mic...

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Detalles Bibliográficos
Autores principales: Dzierba, Carolyn D., Dasgupta, Bireshwar, Karageorge, George, Kostich, Walter, Hamman, Brian, Allen, Jason, Esposito, Kim M., Padmanabha, Ramesh, Grace, James, Lentz, Kimberley, Morrison, John, Morgan, Daniel, Easton, Amy, Bourin, Clotilde, Browning, Marc R., Rajamani, Ramkumar, Good, Andrew, Parker, Dawn D., Muckelbauer, Jodi K., Khan, Javed, Camac, Daniel, Ghosh, Kaushik, Halan, Vivek, Lippy, Jonathan S., Santone, Kenneth S., Denton, R. Rex, Westphal, Ryan, Bristow, Linda J., Conway, Charles M., Bronson, Joanne J., Macor, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238246/
https://www.ncbi.nlm.nih.gov/pubmed/37362320
http://dx.doi.org/10.1007/s00044-023-03079-x

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