The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses

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Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities. The DACH1 gene encodes a winged helix/Forkhead DNA-binding protein that competes for binding to FOXM1 sites. Herein, DACH1 gene deletion within the...

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Detalles Bibliográficos
Autores principales: Li, Zhiping, Jiao, Xuanmao, Robertson, A. Gordon, Di Sante, Gabriele, Ashton, Anthony W., DiRocco, Agnese, Wang, Min, Zhao, Jun, Addya, Sankar, Wang, Chenguang, McCue, Peter A., South, Andrew P., Cordon-Cardo, Carlos, Liu, Runzhi, Patel, Kishan, Hamid, Rasha, Parmar, Jorim, DuHadaway, James B., Jones, Steven J. M., Casimiro, Mathew C., Schultz, Nikolaus, Kossenkov, Andrew, Phoon, Lai Yee, Chen, Hao, Lan, Li, Sun, Yunguang, Iczkowski, Kenneth A., Rui, Hallgeir, Pestell, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238272/
https://www.ncbi.nlm.nih.gov/pubmed/37095257
http://dx.doi.org/10.1038/s41388-023-02668-9
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