Integrating I(I)/I(III) catalysis in reaction cascade design enables the synthesis of gem-difluorinated tetralins from cyclobutanols

Partially saturated, fluorine-containing rings are ubiquitous across the drug discovery spectrum. This capitalises upon the biological significance of the native structure and the physicochemical advantages conferred by fluorination. Motivated by the significance of aryl tetralins in bioactive small...

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Detalles Bibliográficos
Autores principales: Häfliger, Joel, Ruyet, Louise, Stübke, Nico, Daniliuc, Constantin G., Gilmour, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238417/
https://www.ncbi.nlm.nih.gov/pubmed/37268631
http://dx.doi.org/10.1038/s41467-023-38957-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238417/
https://www.ncbi.nlm.nih.gov/pubmed/37268631
http://dx.doi.org/10.1038/s41467-023-38957-w

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