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NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1
Resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) remains one of the major challenges in lung adenocarcinoma (LUAD) therapy. Here, we find an increased frequency of the L12_16 amino acid deletion mutation in the signal peptide region of NOTCH4 (NOTCH4(ΔL12_16)) in EGFR-TKI-...
Autores principales: | Zhang, Bin, Dong, Shaowei, Wang, Jian, Huang, Tuxiong, Zhao, Pan, Xu, Jing, Liu, Dongcheng, Fu, Li, Wang, Lingwei, Wang, Guangsuo, Zou, Chang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238419/ https://www.ncbi.nlm.nih.gov/pubmed/37268635 http://dx.doi.org/10.1038/s41467-023-38833-7 |
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