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NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1

Resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) remains one of the major challenges in lung adenocarcinoma (LUAD) therapy. Here, we find an increased frequency of the L12_16 amino acid deletion mutation in the signal peptide region of NOTCH4 (NOTCH4(ΔL12_16)) in EGFR-TKI-...

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Detalles Bibliográficos
Autores principales:	Zhang, Bin, Dong, Shaowei, Wang, Jian, Huang, Tuxiong, Zhao, Pan, Xu, Jing, Liu, Dongcheng, Fu, Li, Wang, Lingwei, Wang, Guangsuo, Zou, Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238419/ https://www.ncbi.nlm.nih.gov/pubmed/37268635 http://dx.doi.org/10.1038/s41467-023-38833-7

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