Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD(4)-selective WNT surrogate in mice

Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease. The Norrin/FZD(4)/TSPAN12 pathway activates WNT/β-catenin signaling, which is essential for BBB and BRB function. However, syste...

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Detalles Bibliográficos
Autores principales: Ding, Jie, Lee, Sung-Jin, Vlahos, Lukas, Yuki, Kanako, Rada, Cara C., van Unen, Vincent, Vuppalapaty, Meghah, Chen, Hui, Sura, Asmiti, McCormick, Aaron K., Tomaske, Madeline, Alwahabi, Samira, Nguyen, Huy, Nowatzke, William, Kim, Lily, Kelly, Lisa, Vollrath, Douglas, Califano, Andrea, Yeh, Wen-Chen, Li, Yang, Kuo, Calvin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238527/
https://www.ncbi.nlm.nih.gov/pubmed/37268690
http://dx.doi.org/10.1038/s41467-023-37689-1

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