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Human soluble CD39 displays substrate inhibition in a substrate-specific manner

CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD1) metabolizes extracellular ATP and ADP to AMP. AMP is subsequently metabolized by CD79 to adenosine. CD39 activity is therefore a key regulator of purinergic signalling in cancer, thrombosis, and autoimmune diseases. In this study we dem...

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Detalles Bibliográficos
Autores principales:	Vadlamani, Venkat M. K., Gunasinghe, Kavinda K. J., Chee, Xavier W., Rahman, Taufiq, Harper, Matthew T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238538/ https://www.ncbi.nlm.nih.gov/pubmed/37268726 http://dx.doi.org/10.1038/s41598-023-36257-3

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