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New genomic insights into the conformation of Lipizzan horses

Conformation traits are important selection criteria in equine breeding, as they describe the exterior aspects of the horse (height, joint angles, shape). However, the genetic architecture of conformation is not well understood, as data of these traits mainly consist of subjective evaluation scores....

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Autores principales: Gmel, A. I., Brem, G., Neuditschko, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238546/
https://www.ncbi.nlm.nih.gov/pubmed/37268682
http://dx.doi.org/10.1038/s41598-023-36272-4
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author Gmel, A. I.
Brem, G.
Neuditschko, M.
author_facet Gmel, A. I.
Brem, G.
Neuditschko, M.
author_sort Gmel, A. I.
collection PubMed
description Conformation traits are important selection criteria in equine breeding, as they describe the exterior aspects of the horse (height, joint angles, shape). However, the genetic architecture of conformation is not well understood, as data of these traits mainly consist of subjective evaluation scores. Here, we performed genome-wide association studies on two-dimensional shape data of Lipizzan horses. Based on this data, we identified significant quantitative trait loci (QTL) associated with cresty neck on equine chromosome (ECA)16 within the MAGI1 gene, and with type, hereby differentiating heavy from light horses on ECA5 within the POU2F1 gene. Both genes were previously described to affect growth, muscling and fatty deposits in sheep, cattle and pigs. Furthermore, we pin-pointed another suggestive QTL on ECA21, near the PTGER4 gene, associated with human ankylosing spondylitis, for shape differences in the back and pelvis (roach back vs sway back). Further differences in the shape of the back and abdomen were suggestively associated with the RYR1 gene, involved in core muscle weakness in humans. Therefore, we demonstrated that horse shape space data enhance the genomic investigations of horse conformation.
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spelling pubmed-102385462023-06-04 New genomic insights into the conformation of Lipizzan horses Gmel, A. I. Brem, G. Neuditschko, M. Sci Rep Article Conformation traits are important selection criteria in equine breeding, as they describe the exterior aspects of the horse (height, joint angles, shape). However, the genetic architecture of conformation is not well understood, as data of these traits mainly consist of subjective evaluation scores. Here, we performed genome-wide association studies on two-dimensional shape data of Lipizzan horses. Based on this data, we identified significant quantitative trait loci (QTL) associated with cresty neck on equine chromosome (ECA)16 within the MAGI1 gene, and with type, hereby differentiating heavy from light horses on ECA5 within the POU2F1 gene. Both genes were previously described to affect growth, muscling and fatty deposits in sheep, cattle and pigs. Furthermore, we pin-pointed another suggestive QTL on ECA21, near the PTGER4 gene, associated with human ankylosing spondylitis, for shape differences in the back and pelvis (roach back vs sway back). Further differences in the shape of the back and abdomen were suggestively associated with the RYR1 gene, involved in core muscle weakness in humans. Therefore, we demonstrated that horse shape space data enhance the genomic investigations of horse conformation. Nature Publishing Group UK 2023-06-02 /pmc/articles/PMC10238546/ /pubmed/37268682 http://dx.doi.org/10.1038/s41598-023-36272-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gmel, A. I.
Brem, G.
Neuditschko, M.
New genomic insights into the conformation of Lipizzan horses
title New genomic insights into the conformation of Lipizzan horses
title_full New genomic insights into the conformation of Lipizzan horses
title_fullStr New genomic insights into the conformation of Lipizzan horses
title_full_unstemmed New genomic insights into the conformation of Lipizzan horses
title_short New genomic insights into the conformation of Lipizzan horses
title_sort new genomic insights into the conformation of lipizzan horses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238546/
https://www.ncbi.nlm.nih.gov/pubmed/37268682
http://dx.doi.org/10.1038/s41598-023-36272-4
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