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Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches

Chronic wounds remain an unresolved medical issue because of major social and therapeutic repercussions that require extensive focus. Recent related theragnostic focuses only on wound management and is not effectively promoting chronic wound healing. The rising number of patients with either under-h...

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Autores principales: Garima, Sharma, Deepika, Kumar, Arun, Mostafavi, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238601/
https://www.ncbi.nlm.nih.gov/pubmed/37273778
http://dx.doi.org/10.1016/j.omtn.2023.05.002
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author Garima
Sharma, Deepika
Kumar, Arun
Mostafavi, Ebrahim
author_facet Garima
Sharma, Deepika
Kumar, Arun
Mostafavi, Ebrahim
author_sort Garima
collection PubMed
description Chronic wounds remain an unresolved medical issue because of major social and therapeutic repercussions that require extensive focus. Recent related theragnostic focuses only on wound management and is not effectively promoting chronic wound healing. The rising number of patients with either under-healing or over-healing wounds highlights the ineffectiveness of current wound-healing treatments, and thus, there is an unmet need to focus on alternative treatments. To cover this gap, extracellular vesicles (EVs), for targeted delivery of therapeutics, are emerging as a potential therapy to treat both acute and persistent wounds. To address these issues, we explore the core biology of EVs, associated pharmacology, comprehension of immunogenic outcomes, and potential for long-term wound treatment with improved effectiveness and their nonacceptable side effects. Additionally, the therapeutic role of EVs in severe wound infections through biogenetic moderation, in combination with biomaterials (functional in nature), as well as drug carriers that can offer opportunities for the development of new treatments for this long-term condition, are also carefully elaborated, with an emphasis on biomaterial-based drug delivery systems. It is observed that exploring difficulties and potential outcomes of clinical translation of EV-based therapeutics for wound management has the potential to be adopted as a future therapy.
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spelling pubmed-102386012023-06-04 Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches Garima Sharma, Deepika Kumar, Arun Mostafavi, Ebrahim Mol Ther Nucleic Acids Review Chronic wounds remain an unresolved medical issue because of major social and therapeutic repercussions that require extensive focus. Recent related theragnostic focuses only on wound management and is not effectively promoting chronic wound healing. The rising number of patients with either under-healing or over-healing wounds highlights the ineffectiveness of current wound-healing treatments, and thus, there is an unmet need to focus on alternative treatments. To cover this gap, extracellular vesicles (EVs), for targeted delivery of therapeutics, are emerging as a potential therapy to treat both acute and persistent wounds. To address these issues, we explore the core biology of EVs, associated pharmacology, comprehension of immunogenic outcomes, and potential for long-term wound treatment with improved effectiveness and their nonacceptable side effects. Additionally, the therapeutic role of EVs in severe wound infections through biogenetic moderation, in combination with biomaterials (functional in nature), as well as drug carriers that can offer opportunities for the development of new treatments for this long-term condition, are also carefully elaborated, with an emphasis on biomaterial-based drug delivery systems. It is observed that exploring difficulties and potential outcomes of clinical translation of EV-based therapeutics for wound management has the potential to be adopted as a future therapy. American Society of Gene & Cell Therapy 2023-05-09 /pmc/articles/PMC10238601/ /pubmed/37273778 http://dx.doi.org/10.1016/j.omtn.2023.05.002 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garima
Sharma, Deepika
Kumar, Arun
Mostafavi, Ebrahim
Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches
title Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches
title_full Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches
title_fullStr Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches
title_full_unstemmed Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches
title_short Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches
title_sort extracellular vesicle-based biovectors in chronic wound healing: biogenesis and delivery approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238601/
https://www.ncbi.nlm.nih.gov/pubmed/37273778
http://dx.doi.org/10.1016/j.omtn.2023.05.002
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