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Prematurity associated wheeze: Current knowledge and opportunities for further investigation
Prematurity-associated wheeze is a common complication of preterm birth, with significant impact on the health and healthcare utilization of former preterm infants. This wheezing phenotype remains poorly understood and difficult to predict. This review will discuss the current state of the literatur...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238677/ https://www.ncbi.nlm.nih.gov/pubmed/36463364 http://dx.doi.org/10.1038/s41390-022-02404-1 |
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author | Crist, Anna P. Hibbs, Anna Maria |
author_facet | Crist, Anna P. Hibbs, Anna Maria |
author_sort | Crist, Anna P. |
collection | PubMed |
description | Prematurity-associated wheeze is a common complication of preterm birth, with significant impact on the health and healthcare utilization of former preterm infants. This wheezing phenotype remains poorly understood and difficult to predict. This review will discuss the current state of the literature on prematurity associated wheeze. We will discuss etiology and pathophysiology, and offer two conceptual models for the pathogenesis of this complex condition. This review will also identify current methods of ascertainment, and discuss the strengths and limitations of each. We will explore research-backed approaches to prevention and management, and finally suggest both pre-clinical and clinical avenues for investigation. An in-depth understanding of prematurity-associated wheeze will aid clinicians in its diagnosis and management, and inspire scientists to pursue much-needed further study into causes and prevention of this common and impactful condition. |
format | Online Article Text |
id | pubmed-10238677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-102386772023-07-22 Prematurity associated wheeze: Current knowledge and opportunities for further investigation Crist, Anna P. Hibbs, Anna Maria Pediatr Res Article Prematurity-associated wheeze is a common complication of preterm birth, with significant impact on the health and healthcare utilization of former preterm infants. This wheezing phenotype remains poorly understood and difficult to predict. This review will discuss the current state of the literature on prematurity associated wheeze. We will discuss etiology and pathophysiology, and offer two conceptual models for the pathogenesis of this complex condition. This review will also identify current methods of ascertainment, and discuss the strengths and limitations of each. We will explore research-backed approaches to prevention and management, and finally suggest both pre-clinical and clinical avenues for investigation. An in-depth understanding of prematurity-associated wheeze will aid clinicians in its diagnosis and management, and inspire scientists to pursue much-needed further study into causes and prevention of this common and impactful condition. 2023-07 2022-12-03 /pmc/articles/PMC10238677/ /pubmed/36463364 http://dx.doi.org/10.1038/s41390-022-02404-1 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Crist, Anna P. Hibbs, Anna Maria Prematurity associated wheeze: Current knowledge and opportunities for further investigation |
title | Prematurity associated wheeze: Current knowledge and opportunities for further investigation |
title_full | Prematurity associated wheeze: Current knowledge and opportunities for further investigation |
title_fullStr | Prematurity associated wheeze: Current knowledge and opportunities for further investigation |
title_full_unstemmed | Prematurity associated wheeze: Current knowledge and opportunities for further investigation |
title_short | Prematurity associated wheeze: Current knowledge and opportunities for further investigation |
title_sort | prematurity associated wheeze: current knowledge and opportunities for further investigation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238677/ https://www.ncbi.nlm.nih.gov/pubmed/36463364 http://dx.doi.org/10.1038/s41390-022-02404-1 |
work_keys_str_mv | AT cristannap prematurityassociatedwheezecurrentknowledgeandopportunitiesforfurtherinvestigation AT hibbsannamaria prematurityassociatedwheezecurrentknowledgeandopportunitiesforfurtherinvestigation |