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Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study
BACKGROUND: The aim of the present study was to evaluate the diagnostic performance of monocyte distribution width (MDW) as a biomarker for sepsis diagnosis in severe patients attended in the Emergency Department for different conditions and not only infections. METHODS: We performed an observationa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedad Española de Quimioterapia
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238791/ https://www.ncbi.nlm.nih.gov/pubmed/36935618 http://dx.doi.org/10.37201/req/108.2022 |
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author | Encabo, Marta Hernández-Álvarez, Elena Oteo, David García-Álvarez, Ana González, Mercedes Martínez-Novillo Sanz-Casla, María Teresa Castillo, Juan González-del |
author_facet | Encabo, Marta Hernández-Álvarez, Elena Oteo, David García-Álvarez, Ana González, Mercedes Martínez-Novillo Sanz-Casla, María Teresa Castillo, Juan González-del |
author_sort | Encabo, Marta |
collection | PubMed |
description | BACKGROUND: The aim of the present study was to evaluate the diagnostic performance of monocyte distribution width (MDW) as a biomarker for sepsis diagnosis in severe patients attended in the Emergency Department for different conditions and not only infections. METHODS: We performed an observational study in a consecutive prospective cohort including severe patients attending the Emergency Department with different conditions. MDW and other biomarkers were determined from samples obtained during the first care of patients. The diagnostic performance of the different biomarkers was determined based on the final diagnosis at patient discharge. RESULTS: One hundred two patients, with a mean age of 76.7 (SD 16.5) years were included, 53 being (51.9%) male. Among the patients included, 65 (63.7%) had an infectious disease while the remaining had other different conditions. A MDW cut-off of 20.115 provided the best accuracy to identify infected patients, with a sensitivity of 89.2 (95% CI 79.4-94.7), a specificity of 89.2 (95% CI 75.3-95.7), a positive predictive value of 93.5 (95% CI 84.6-97.5), a negative predictive value of 82.5% (95% CI 68.0-91.3), a positive likelihood ratio of 8.25 (3.26-20.91), and a negative likelihood ratio of 0.12 (0.06-0.24). The area under the receiver operating characteristic curve for infection according to MDW was 0.943 (95% CI 0.897-0.989; p<0.001). CONCLUSIONS: A MDW > 20.115 may be associated with infection and could help to distinguish between infected and non-infected patients in severe patients. These results must be confirmed in new studies due to the limited patient sample included. |
format | Online Article Text |
id | pubmed-10238791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedad Española de Quimioterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-102387912023-06-04 Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study Encabo, Marta Hernández-Álvarez, Elena Oteo, David García-Álvarez, Ana González, Mercedes Martínez-Novillo Sanz-Casla, María Teresa Castillo, Juan González-del Rev Esp Quimioter Original BACKGROUND: The aim of the present study was to evaluate the diagnostic performance of monocyte distribution width (MDW) as a biomarker for sepsis diagnosis in severe patients attended in the Emergency Department for different conditions and not only infections. METHODS: We performed an observational study in a consecutive prospective cohort including severe patients attending the Emergency Department with different conditions. MDW and other biomarkers were determined from samples obtained during the first care of patients. The diagnostic performance of the different biomarkers was determined based on the final diagnosis at patient discharge. RESULTS: One hundred two patients, with a mean age of 76.7 (SD 16.5) years were included, 53 being (51.9%) male. Among the patients included, 65 (63.7%) had an infectious disease while the remaining had other different conditions. A MDW cut-off of 20.115 provided the best accuracy to identify infected patients, with a sensitivity of 89.2 (95% CI 79.4-94.7), a specificity of 89.2 (95% CI 75.3-95.7), a positive predictive value of 93.5 (95% CI 84.6-97.5), a negative predictive value of 82.5% (95% CI 68.0-91.3), a positive likelihood ratio of 8.25 (3.26-20.91), and a negative likelihood ratio of 0.12 (0.06-0.24). The area under the receiver operating characteristic curve for infection according to MDW was 0.943 (95% CI 0.897-0.989; p<0.001). CONCLUSIONS: A MDW > 20.115 may be associated with infection and could help to distinguish between infected and non-infected patients in severe patients. These results must be confirmed in new studies due to the limited patient sample included. Sociedad Española de Quimioterapia 2023-03-20 2023 /pmc/articles/PMC10238791/ /pubmed/36935618 http://dx.doi.org/10.37201/req/108.2022 Text en © The Author 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/). |
spellingShingle | Original Encabo, Marta Hernández-Álvarez, Elena Oteo, David García-Álvarez, Ana González, Mercedes Martínez-Novillo Sanz-Casla, María Teresa Castillo, Juan González-del Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study |
title | Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study |
title_full | Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study |
title_fullStr | Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study |
title_full_unstemmed | Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study |
title_short | Monocyte distribution width (MDW) as an infection indicator in severe patients attending in the Emergency Department: a pilot study |
title_sort | monocyte distribution width (mdw) as an infection indicator in severe patients attending in the emergency department: a pilot study |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238791/ https://www.ncbi.nlm.nih.gov/pubmed/36935618 http://dx.doi.org/10.37201/req/108.2022 |
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