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Application of the patient-reported outcomes continual reassessment method to a phase I study of radiotherapy in endometrial cancer
This article considers the concept of designing Phase I clinical trials using both clinician- and patient-reported outcomes to adaptively allocate study participants to tolerable doses and determine the maximum tolerated dose (MTD) at the study conclusion. We describe an application of a Bayesian fo...
Autores principales: | Wages, Nolan A., Nelson, Bailey, Kharofa, Jordan, Meier, Teresa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238853/ https://www.ncbi.nlm.nih.gov/pubmed/36394530 http://dx.doi.org/10.1515/ijb-2022-0023 |
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