A QTL on chromosome IV explains a natural variation of QR.pap final position in Caenorhabditis elegans

In Caenorhabditis elegans , the QR neuroblast and its progeny migrate from the posterior to the anterior part of the animal during the L1 stage. We previously showed that the final position of QR.pa daughters varies among C. elegans wild isolates, with CB4932 displaying a particularly anterior QR.pa...

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Detalles Bibliográficos
Autores principales: Dubois, Clément, Félix, Marie-Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238922/
https://www.ncbi.nlm.nih.gov/pubmed/37273577
http://dx.doi.org/10.17912/micropub.biology.000836
Descripción
Sumario:In Caenorhabditis elegans , the QR neuroblast and its progeny migrate from the posterior to the anterior part of the animal during the L1 stage. We previously showed that the final position of QR.pa daughters varies among C. elegans wild isolates, with CB4932 displaying a particularly anterior QR.pap position (Dubois et al., 2021). Here, we study the genetic basis of the variation between isolates CB4932 and JU1242. We show that JU1242 alleles behave in a mostly dominant fashion. Using a Bulk Segregant Analysis, we detect a quantitative trait locus (QTL) region on chromosome IV. This QTL was confirmed using reciprocal chromosome IV introgressions.

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