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Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study

BACKGROUND: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. AIMS: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibil...

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Autores principales: Mustafa, Amany I., Shams, Ghada M., Fawzy, Eman M., Alhusseini, Naglaa F., Khashaba, Rana A., EL-Shimi, Ola S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239005/
https://www.ncbi.nlm.nih.gov/pubmed/37275815
http://dx.doi.org/10.4103/ijd.ijd_1001_22
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author Mustafa, Amany I.
Shams, Ghada M.
Fawzy, Eman M.
Alhusseini, Naglaa F.
Khashaba, Rana A.
EL-Shimi, Ola S.
author_facet Mustafa, Amany I.
Shams, Ghada M.
Fawzy, Eman M.
Alhusseini, Naglaa F.
Khashaba, Rana A.
EL-Shimi, Ola S.
author_sort Mustafa, Amany I.
collection PubMed
description BACKGROUND: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. AIMS: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibility of SFIs among a group of Egyptian patients. MATERIALS AND METHODS: Standard laboratory methods were used to estimate the serum lipid profile, and polymerase chain reaction–restriction fragment length polymorphism was used to detect APOE gene polymorphism in deoxyribonucleic acid extracted from 150 SFI patients and an equal number of apparently healthy matched controls. RESULTS: Serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly higher in the studied patients than in controls. The APOE gene ε2, ε4 alleles, and ε3/4 and ε3/2 genotypes were significantly distributed in the patients than in the controls. APOE ε3/3 genotype was predominant in dermatophytosis and tinea versicolour patients, and ε3/4 genotype was predominant in candidiasis. CONCLUSIONS: ApoE alleles ε2 and ε4, and genotypes ε2/3 and ε3/4 are linked to SFI and may be risk factors, whereas allele ε3 and genotype ε3/3 may be protective for SFI in the Egyptian population studied. The lipid profile results suggest that hyperlipidemia may provide evidence for SFI pathogenesis. However; further large-scale studies are still needed to validate our results.
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spelling pubmed-102390052023-06-04 Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study Mustafa, Amany I. Shams, Ghada M. Fawzy, Eman M. Alhusseini, Naglaa F. Khashaba, Rana A. EL-Shimi, Ola S. Indian J Dermatol Original Article BACKGROUND: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities. AIMS: The present work intended to investigate the association of APOE gene polymorphism and serum lipids with the susceptibility of SFIs among a group of Egyptian patients. MATERIALS AND METHODS: Standard laboratory methods were used to estimate the serum lipid profile, and polymerase chain reaction–restriction fragment length polymorphism was used to detect APOE gene polymorphism in deoxyribonucleic acid extracted from 150 SFI patients and an equal number of apparently healthy matched controls. RESULTS: Serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol were significantly higher in the studied patients than in controls. The APOE gene ε2, ε4 alleles, and ε3/4 and ε3/2 genotypes were significantly distributed in the patients than in the controls. APOE ε3/3 genotype was predominant in dermatophytosis and tinea versicolour patients, and ε3/4 genotype was predominant in candidiasis. CONCLUSIONS: ApoE alleles ε2 and ε4, and genotypes ε2/3 and ε3/4 are linked to SFI and may be risk factors, whereas allele ε3 and genotype ε3/3 may be protective for SFI in the Egyptian population studied. The lipid profile results suggest that hyperlipidemia may provide evidence for SFI pathogenesis. However; further large-scale studies are still needed to validate our results. Wolters Kluwer - Medknow 2023 /pmc/articles/PMC10239005/ /pubmed/37275815 http://dx.doi.org/10.4103/ijd.ijd_1001_22 Text en Copyright: © 2023 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mustafa, Amany I.
Shams, Ghada M.
Fawzy, Eman M.
Alhusseini, Naglaa F.
Khashaba, Rana A.
EL-Shimi, Ola S.
Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study
title Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study
title_full Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study
title_fullStr Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study
title_full_unstemmed Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study
title_short Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients – A Preliminary Case-Controlled Study
title_sort apolipoprotein e gene polymorphism, serum lipids, and risk of superficial fungal infections in egyptian patients – a preliminary case-controlled study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239005/
https://www.ncbi.nlm.nih.gov/pubmed/37275815
http://dx.doi.org/10.4103/ijd.ijd_1001_22
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