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Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart

Since the beginning of the SARS-CoV-2 pandemic, studies on the variants and sublineages stand out, mainly in the cases of reinfection in a short period. In this study, we describe a case of infection by BA.1.1 sublineage in an individual from Southern Brazil. The same patient acquired reinfection wi...

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Autores principales: Girardi, Viviane, Gularte, Juliana Schons, Demoliner, Meriane, da Silva, Mariana Soares, Filippi, Micheli, de Abreu Góes Pereira, Vyctoria Malayhka, Hansen, Alana Witt, Rosa, Raquel Borba, Fleck, Juliane Deise, Spilki, Fernando Rosado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239041/
https://www.ncbi.nlm.nih.gov/pubmed/37269428
http://dx.doi.org/10.1007/s42770-023-01018-x
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author Girardi, Viviane
Gularte, Juliana Schons
Demoliner, Meriane
da Silva, Mariana Soares
Filippi, Micheli
de Abreu Góes Pereira, Vyctoria Malayhka
Hansen, Alana Witt
Rosa, Raquel Borba
Fleck, Juliane Deise
Spilki, Fernando Rosado
author_facet Girardi, Viviane
Gularte, Juliana Schons
Demoliner, Meriane
da Silva, Mariana Soares
Filippi, Micheli
de Abreu Góes Pereira, Vyctoria Malayhka
Hansen, Alana Witt
Rosa, Raquel Borba
Fleck, Juliane Deise
Spilki, Fernando Rosado
author_sort Girardi, Viviane
collection PubMed
description Since the beginning of the SARS-CoV-2 pandemic, studies on the variants and sublineages stand out, mainly in the cases of reinfection in a short period. In this study, we describe a case of infection by BA.1.1 sublineage in an individual from Southern Brazil. The same patient acquired reinfection with sublineage BA.2 within 16 days after the first detection. The viral extraction and RT-qPCR were performed on the samples LMM72045 (collected in May 2022) and LMM72044 (collected in June 2022). After the confirmation of SARS-CoV-2 infection, we conducted the sequencing and viral genome analysis. This case of reinfection affected a 52-year-old male patient, without comorbidities, with three doses of vaccines against COVID-19, showing symptoms on May 19. These symptoms lasted for approximately six days. The patient returned to work activities on May 30. However, on June 4, the patient felt a new round of clinical signs that lasted for approximately seven days. Analysis of the viral genomes recovered from patients’ clinical samples revealed that the two COVID-19 episodes were related to two divergent VOC Omicron sublineages, namely, BA.1.1 for the first round of symptoms and BA.2 for the second infection. Based on our findings, we can say that the present case of reinfection is the shortest described so far.
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spelling pubmed-102390412023-06-06 Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart Girardi, Viviane Gularte, Juliana Schons Demoliner, Meriane da Silva, Mariana Soares Filippi, Micheli de Abreu Góes Pereira, Vyctoria Malayhka Hansen, Alana Witt Rosa, Raquel Borba Fleck, Juliane Deise Spilki, Fernando Rosado Braz J Microbiol Clinical Microbiology - Short Communication Since the beginning of the SARS-CoV-2 pandemic, studies on the variants and sublineages stand out, mainly in the cases of reinfection in a short period. In this study, we describe a case of infection by BA.1.1 sublineage in an individual from Southern Brazil. The same patient acquired reinfection with sublineage BA.2 within 16 days after the first detection. The viral extraction and RT-qPCR were performed on the samples LMM72045 (collected in May 2022) and LMM72044 (collected in June 2022). After the confirmation of SARS-CoV-2 infection, we conducted the sequencing and viral genome analysis. This case of reinfection affected a 52-year-old male patient, without comorbidities, with three doses of vaccines against COVID-19, showing symptoms on May 19. These symptoms lasted for approximately six days. The patient returned to work activities on May 30. However, on June 4, the patient felt a new round of clinical signs that lasted for approximately seven days. Analysis of the viral genomes recovered from patients’ clinical samples revealed that the two COVID-19 episodes were related to two divergent VOC Omicron sublineages, namely, BA.1.1 for the first round of symptoms and BA.2 for the second infection. Based on our findings, we can say that the present case of reinfection is the shortest described so far. Springer International Publishing 2023-06-03 /pmc/articles/PMC10239041/ /pubmed/37269428 http://dx.doi.org/10.1007/s42770-023-01018-x Text en © The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia 2023
spellingShingle Clinical Microbiology - Short Communication
Girardi, Viviane
Gularte, Juliana Schons
Demoliner, Meriane
da Silva, Mariana Soares
Filippi, Micheli
de Abreu Góes Pereira, Vyctoria Malayhka
Hansen, Alana Witt
Rosa, Raquel Borba
Fleck, Juliane Deise
Spilki, Fernando Rosado
Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart
title Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart
title_full Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart
title_fullStr Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart
title_full_unstemmed Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart
title_short Reinfection by SARS-CoV-2 by divergent Omicron sublineages, 16 days apart
title_sort reinfection by sars-cov-2 by divergent omicron sublineages, 16 days apart
topic Clinical Microbiology - Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239041/
https://www.ncbi.nlm.nih.gov/pubmed/37269428
http://dx.doi.org/10.1007/s42770-023-01018-x
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